No association between the DRD3 Ser9Gly polymorphism and schizophrenia

被引：20

作者：

Fathalli, Ferid ^{[1
,2
]}

Rouleau, Guy A. ^{[2
,3
]}

Xiong, Lan ^{[3
]}

Tabbane, Karim ^{[4
]}

Benkelfat, Chawki ^{[5
]}

Deguzman, Rosherrie ^{[1
]}

Zoltan, Danics ^{[6
]}

Lal, Samarthji ^{[1
,5
]}

D'cruz, Sarogini ^{[1
]}

Joober, Ridha ^{[1
,5
]}

机构：

[1] Douglas Hosp, Res Ctr, Verdun, PQ H4H 1R3, Canada

[2] Univ Montreal, Montreal, PQ, Canada

[3] Univ Montreal, Notre Dame Hosp, Res Ctr, CHUM, Montreal, PQ H2L 4M1, Canada

[4] Univ Tunis, Dept Psychiat, Tunis, Tunisia

[5] McGill Univ, Dept Psychiat, Montreal, PQ, Canada

[6] Natl Inst Psychiat, Budapest, Hungary

来源：

SCHIZOPHRENIA RESEARCH | 2008年 / 98卷 / 1-3期

基金：

加拿大健康研究院;

关键词：

schizophrenia; DRD3 (dopamine D3 receptor gene); association study; neuroleptic response;

D O I：

10.1016/j.schres.2007.07.002

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective: To investigate the association between a Ser9Gly polymorphism of die dopamine D3 receptor gene (DRD3) and schizophrenia. Methods: 408 schizophrenic patients and 172 control subjects were compared with regard to their DRD3 Ser9Gly genotypic and allelic frequencies. In addition, we carried out a family-based association study including 183 pedigrees (472 subjects) using the transmission disequilibrium test (TDT). Results: No significant differences of genotype or homozygosity distribution were identified between patients and controls. When patients were stratified according to gender, response to treatment, age at onset, no significant differences were observed. Neither allele A (Set), or G (Gly) were preferentially transmitted from parents to affected offspring. Conclusion: The hypothesis that the DRD3 Ser9Gly polymorphism plays a predisposing role in schizophrenia is not supported by this study. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：98 / 104

页数：7

共 72 条

[1]

Asherson P, 1996, MOL PSYCHIATR, V1, P125

[2] Association of the MscI polymorphism of the dopamine D3 receptor gene with tardive dyskinesia in schizophrenia [J].

Basile, VS ;

Masellis, M ;

Badri, F ;

Paterson, AD ;

Meltzer, HY ;

Lieberman, JA ;

Potkin, SG ;

Macciardi, F ;

Kennedy, JL .

NEUROPSYCHOPHARMACOLOGY, 1999, 21 (01) :17-27

[3]

Bogerts B, 1999, EUR ARCH PSY CLIN N, V249, P2

[4] Neonatal origins of schizophrenia [J].

Cannon, M ;

Murray, RM .

ARCHIVES OF DISEASE IN CHILDHOOD, 1998, 78 (01) :1-3

[5]

CARLSSON A, 1963, ACTA PHARMACOL TOX, V20, P140

[6]

Chen CH, 1997, AM J MED GENET, V74, P40, DOI 10.1002/(SICI)1096-8628(19970221)74:1<40::AID-AJMG9>3.0.CO

[7]

2-Z

[8] Polymorphisms of dopamine receptors and tardive dyskinesia among Chinese patients with schizophrenia [J].

Chong, SA ;

Tan, EC ;

Tan, CH ;

Mythily ;

Chan, YH .

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2003, 116B (01) :51-54

[9] ASSOCIATION BETWEEN SCHIZOPHRENIA AND HOMOZYGOSITY AT THE DOPAMINE-D3 RECEPTOR GENE [J].

CROCQ, MA ;

MANT, R ;

ASHERSON, P ;

WILLIAMS, J ;

HODE, Y ;

MAYEROVA, A ;

COLLIER, D ;

LANNFELT, L ;

SOKOLOFF, P ;

SCHWARTZ, JC ;

GILL, M ;

MACHER, JP ;

MCGUFFIN, P ;

OWEN, MJ .

JOURNAL OF MEDICAL GENETICS, 1992, 29 (12) :858-860

[10] Genetic polymorphisms of the dopamine D2 and D3 receptor and neuroleptic drug effects in schizophrenic patients [J].

Dahmen, N ;

Müller, MJ ;

Germeyer, S ;

Rujescu, D ;

Anghelescu, I ;

Hiemke, C ;

Wetzel, H .

SCHIZOPHRENIA RESEARCH, 2001, 49 (1-2) :223-225

← 1 2 3 4 5 6 7 8 →