One-pot synthesis of novel fused mesoionic compounds: 1-substituted-5-thioxo-5,6-dihydro-[1,2,4]triazolo[1,5-c]quinazolin-1-ium-2-thiolates

被引：0
|
作者：
Kovalenko, Sergiy M. [1 ]
Drushlyak, Oleksandr G. [2 ]
Mariutsa, Illia O. [2 ]
机构：
[1] Kharkov Natl Univ, Dept Organ Chem, Kharkiv, Ukraine
[2] Natl Univ Pharm, Fac Pharm, 53 Pushkinska St, UA-61002 Kharkiv, Ukraine
来源：
JOURNAL OF SULFUR CHEMISTRY | 2020年 / 41卷 / 04期
关键词：
Condensation; cyclization; heterocycles; thiols; ylides; BIOLOGICAL EVALUATION; PHARMACOLOGICAL EVALUATION; PARALLEL SYNTHESIS; ANTITUMOR-ACTIVITY; DERIVATIVES; INHIBITORS; RECEPTOR; HETEROCYCLES; ANTICANCER;
D O I：
10.1080/17415993.2020.1742714
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Novel 1-substituted-5-thioxo-5,6-dihydro-[1,2,4]triazolo[1,5-c]quinazolin-1-ium-2-thiolates have been obtained by base catalyzed condensation of methyl 2-isothiocyanatobenzoate with thiosemicarbazides. The reaction occurs via intermediate N-(4-oxo-2-thioxo-1,4-dihydroquinazolin-3(2H)-yl)thioureas followed by cyclization with elimination of the oxygen atom as water and the angular product formation. All new synthesized compounds were fully characterized with elemental and spectroscopic analysis.
引用
收藏
页码：388 / 398
页数：11
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