Hub disruption in patients with chronic neck pain: a graph analytical approach

被引:20
作者
De Pauw, Robby [1 ]
Aerts, Hannelore [2 ]
Siugzdaite, Roma [3 ]
Meeus, Mira [1 ,4 ,5 ]
Coppieters, Iris [1 ,4 ,6 ]
Caeyenberghs, Karen [1 ,7 ]
Cagnie, Barbara [1 ]
机构
[1] Univ Ghent, Fac Med & Hlth Sci, Dept Rehabil Sci & Physiotherapy, Ghent, Belgium
[2] Univ Ghent, Fac Psychol & Educ Sci, Dept Data Anal, Ghent, Belgium
[3] Univ Ghent, Fac Psychol & Educ Sci, Expt Psychol Dept, Ghent, Belgium
[4] Univ Antwerp, Fac Med & Hlth Sci, Pain Mot Int Res Grp, Antwerp, Belgium
[5] Univ Antwerp, Fac Med & Hlth Sci, Dept Rehabil Sci & Physiotherapy, Antwerp, Belgium
[6] Vrije Univ Brussel, Physiotherapy Human Physiol & Anat KIMA, Brussels, Belgium
[7] Deakin Univ, Cognit Neurosci Unit, Sch Psychol, Geelong, Vic, Australia
关键词
Whiplash; Brain imaging; Idiopathic neck pain; Graph theory; HDI; Network topology; Connectomics; WHIPLASH-ASSOCIATED DISORDERS; BRAIN FUNCTIONAL NETWORKS; DEFAULT-MODE NETWORK; CENTRAL SENSITIZATION; DISABILITY-INDEX; AMYGDALA; OPTIMIZATION; REGISTRATION; RELIABILITY; PERFORMANCE;
D O I
10.1097/j.pain.0000000000001762
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Chronic pain is known to alter the brain's network dynamics. These dynamics are often demonstrated by identifying alterations in the brain network topology. A common approach used for this purpose is graph theory. To date, little is known on how these potentially altered networks in chronic pain relate to the symptoms reported by these patients. Here, we applied a graph theoretical approach to identify network changes in patients suffering from chronic neck pain, a group that is often neglected in chronic pain research. Participants with chronic traumatic and nontraumatic neck pain were compared to healthy pain-free controls. They showed higher levels of self-reported symptoms of sensitization, higher levels of disability, and impaired sensorimotor control. Furthermore, the brain suffering from chronic neck pain showed altered network properties in the posterior cingulate cortex, amygdala, and pallidum compared with the healthy pain-free brain. These regions have been identified as brain hubs (ie, regions that are responsible for orchestrating communication between other brain regions) and are therefore known to be more vulnerable in brain disorders including chronic pain. We were furthermore able to uncover associations between these altered brain network properties and the symptoms reported by patients. Our findings indicate that chronic neck pain patients reflect brain network alterations and that targeting the brain in patients might be of utmost importance.
引用
收藏
页码:729 / 741
页数:13
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