Implications of Gut Microbiota in Complex Human Diseases

被引：34

作者：

Yu, Dahai ^{[1
]}

Meng, Xin ^{[1
]}

de Vos, Willem M. ^{[2
,3
]}

Wu, Hao ^{[4
,5
]}

Fang, Xuexun ^{[1
]}

Maiti, Amit K. ^{[6
]}

机构：

[1] Jilin Univ, Sch Life Sci, Minist Educ, Key Lab Mol Enzymol & Engn, 2699 Qianjin St, Changchun 130012, Peoples R China

[2] Wageningen Univ, Microbiol Lab, Dreijenpl 10, NL-6703 HB Wageningen, Netherlands

[3] Univ Helsinki, Fac Med, Human Microbiome Res Program, Helsinki 00014, Finland

[4] Boston Childrens Hosp, Dept Surg, Vasc Biol Program, Boston, MA 02115 USA

[5] Harvard Med Sch, Boston, MA 02115 USA

[6] Mydnavar, Dept Genet & Genom, 2645 Somerset Blvd, Troy, MI 48084 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 23期

关键词：

gut; microbiota; disease; bacteria; FMT; CHAIN FATTY-ACIDS; BIFIDOBACTERIUM-LONGUM NCC3001; HELICOBACTER-PYLORI INFECTION; DIET-INDUCED OBESITY; FECAL MICROBIOTA; FUSOBACTERIUM-NUCLEATUM; COLORECTAL-CANCER; COLONIC INFLAMMATION; CAMPYLOBACTER-JEJUNI; METABOLITE BUTYRATE;

D O I：

10.3390/ijms222312661

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Humans, throughout the life cycle, from birth to death, are accompanied by the presence of gut microbes. Environmental factors, lifestyle, age and other factors can affect the balance of intestinal microbiota and their impact on human health. A large amount of data show that dietary, prebiotics, antibiotics can regulate various diseases through gut microbes. In this review, we focus on the role of gut microbes in the development of metabolic, gastrointestinal, neurological, immune diseases and, cancer. We also discuss the interaction between gut microbes and the host with respect to their beneficial and harmful effects, including their metabolites, microbial enzymes, small molecules and inflammatory molecules. More specifically, we evaluate the potential ability of gut microbes to cure diseases through Fecal Microbial Transplantation (FMT), which is expected to become a new type of clinical strategy for the treatment of various diseases.

引用

页数：33

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