Flavonoids as Cytokine Modulators: A Possible Therapy for Inflammation-Related Diseases

被引：239

作者：

Leyva-Lopez, Nayely ^{[1
]}

Gutierrez-Grijalva, Erick P. ^{[1
]}

Ambriz-Perez, Dulce L. ^{[2
]}

Basilio Heredia, J. ^{[1
]}

机构：

[1] Ctr Invest Alimentac & Desarrollo AC, Carretera Eldorado Km 5-5 Col El Diez, Culiacan 80110, Sinaloa, Mexico

[2] Univ Politecn Mar & Sierra, Carretera Potrerillos Norote La Cruz Km 3, Elota 82740, Sinaloa, Mexico

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2016年 / 17卷 / 06期

关键词：

flavonoids; anti-inflammatory effect; cytokine inhibition; NF-KAPPA-B; LIPOPOLYSACCHARIDE (LPS)-INDUCED INFLAMMATION; AMYLOID BETA-PEPTIDE; RHEUMATOID-ARTHRITIS; PROTECTIVE ROLE; ANTIINFLAMMATORY ACTIVITY; INTERLEUKIN-6; RECEPTOR; AUTOIMMUNE-DISEASES; SIGNALING PATHWAY; PLANT FLAVONOIDS;

D O I：

10.3390/ijms17060921

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

High levels of cytokines, such as interleukin (IL)-1 beta, tumor necrosis factor (TNF)-alpha and IL-6, are associated with chronic diseases like rheumatoid arthritis, asthma, atherosclerosis, Alzheimer's disease and cancer; therefore cytokine inhibition might be an important target for the treatment of these diseases. Most drugs used to alleviate some inflammation-related symptoms act by inhibiting cyclooxygenases activity or by blocking cytokine receptors. Nevertheless, these drugs have secondary effects when used on a long-term basis. It has been mentioned that flavonoids, namely quercetin, apigenin and luteolin, reduce cytokine expression and secretion. In this regard, flavonoids may have therapeutical potential in the treatment of inflammation-related diseases as cytokine modulators. This review is focused on current research about the effect of flavonoids on cytokine modulation and the description of the way these compounds exert their effect.

引用

页数：15

共 113 条

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