The Mitochondrial Na+/Ca2+ Exchanger is Necessary but Not Sufficient for Ca2+ Homeostasis and Viability

被引：6

作者：

Liu, Timon Cheng-Yi ^{[1
]}

Tang, Xiao-Ming ^{[1
]}

Duan, Rui ^{[1
]}

Ma, Lei ^{[2
]}

Zhu, Ling ^{[1
]}

Zhang, Quan-Guang ^{[1
]}

机构：

[1] South China Normal Univ, Lab Laser Sports Med, Guangzhou, Guangdong, Peoples R China

[2] Nantong Univ, Sch Elect Informat, Nantong, Peoples R China

来源：

OXYGEN TRANSPORT TO TISSUE XL | 2018年 / 1072卷

基金：

美国国家科学基金会; 国家教育部博士点专项基金资助;

关键词：

D O I：

10.1007/978-3-319-91287-5_45

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Luongo et al. found that the mitochondrial Na+/Ca2+ exchanger (NCLX) was essential for Ca2+ homeostasis and viability. Here, we re-analyze their data in terms of fractal self-similarity and quantitative difference (QD). We calculated the 7-dimension data from NCLX conditional loss-of-function mouse models, and the 9-dimension data from NCLX overexpression (NCLX-Tg) models. Results: The 9-dimension data of the NCLX-Tg and its tTA control were partially self-similar to each other, while the 7-dimension data in NCLX knockout models were not. Conclusion: The NCLX may be necessary but is not sufficient for Ca2+ homeostasis and viability.

引用

页码：281 / 285

页数：5

共 50 条

[31] mitochondrial Ca2+ processing unit (mitochondrial Ca2+ uniporter and Na+/Ca2+ exchanger) is crucial for regulation of glutamate receptor-mediated Ca2+ influx in neurons.
Reiser, G.
Strokin, M.
MOLECULAR BIOLOGY OF THE CELL, 2015, 26
[32] The Mitochondrial Na+/Ca2+ Exchanger Upregulates Glucose Dependent Ca2+ Signalling Linked to Insulin Secretion
Nita, Iulia I.
Hershfinkel, Michal
Fishman, Daniel
Ozeri, Eyal
Rutter, Guy A.
Sensi, Stefano L.
Khananshvili, Daniel
Lewis, Eli C.
Sekler, Israel
PLOS ONE, 2012, 7 (10):
[33] Na+/Ca2+ exchanger, learning, and memory
不详
NEUROSCIENTIST, 2003, 9 (06): : 427 - 427
[34] Topics on the Na+/Ca2+ exchanger:: Preface
Kimura, Junko
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2006, 102 (01) : 6 - 6
[35] Shedding light on the Na+/Ca2+ exchanger
Ottolia, Michela
John, Scott
Xie, Yi
Ren, Xiaoyan
Philipson, Kenneth D.
SODIUM-CALCIUM EXCHANGE AND THE PLASMA MEMBRANE CA2+-ATPASE IN CELL FUNCTION: FIFTH INTERNATIONAL CONFERENCE, 2007, 1099 : 78 - 85
[36] Transcriptional control of the Na+/Ca2+ exchanger
Gabellini, N
Zatti, A
Carafoli, E
CONTROL AND DISEASES OF SODIUM DEPENDENT TRANSPORT PROTEINS AND ION CHANNELS, 2000, 1208 : 69 - 72
[37] IS THERE A NA+/CA2+ EXCHANGER IN MACROPHAGES AND IN LYMPHOCYTES
DONNADIEU, E
TRAUTMANN, A
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1993, 424 (5-6): : 448 - 455
[38] Na+/Ca2+ exchanger in porcine oocytes
Macháty, Z
Ramsoondar, JJ
Bonk, AJ
Prather, RS
Bondioli, KR
BIOLOGY OF REPRODUCTION, 2002, 67 (04) : 1133 - 1139
[39] Enhanced SR Ca2+ content in Na+/Ca2+ exchanger (±) mouse heart
Takamatsu, H
Ohtsuka, M
Akazawa, H
Ichijo, H
Komuro, I
Adachi-Akahane, S
BIOPHYSICAL JOURNAL, 2003, 84 (02) : 433A - 433A
[40] Zinc inhibits Ca2+ transport by rat brain Na+/Ca2+ exchanger
Colvin, RA
NEUROREPORT, 1998, 9 (13) : 3091 - 3096

← 1 2 3 4 5 →