The Mitochondrial Na+/Ca2+ Exchanger is Necessary but Not Sufficient for Ca2+ Homeostasis and Viability

被引：6
|
作者：
Liu, Timon Cheng-Yi [1 ]
Tang, Xiao-Ming [1 ]
Duan, Rui [1 ]
Ma, Lei [2 ]
Zhu, Ling [1 ]
Zhang, Quan-Guang [1 ]
机构：
[1] South China Normal Univ, Lab Laser Sports Med, Guangzhou, Guangdong, Peoples R China
[2] Nantong Univ, Sch Elect Informat, Nantong, Peoples R China
来源：
OXYGEN TRANSPORT TO TISSUE XL | 2018年 / 1072卷
基金：
美国国家科学基金会; 国家教育部博士点专项基金资助;
关键词：
D O I：
10.1007/978-3-319-91287-5_45
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Luongo et al. found that the mitochondrial Na+/Ca2+ exchanger (NCLX) was essential for Ca2+ homeostasis and viability. Here, we re-analyze their data in terms of fractal self-similarity and quantitative difference (QD). We calculated the 7-dimension data from NCLX conditional loss-of-function mouse models, and the 9-dimension data from NCLX overexpression (NCLX-Tg) models. Results: The 9-dimension data of the NCLX-Tg and its tTA control were partially self-similar to each other, while the 7-dimension data in NCLX knockout models were not. Conclusion: The NCLX may be necessary but is not sufficient for Ca2+ homeostasis and viability.
引用
收藏
页码：281 / 285
页数：5
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