Chitosan nanoparticles as a novel delivery system for ammonium glycyrrhizinate

被引：414
作者：
Wu, Y [1 ]
Yang, WL [1 ]
Wang, CC [1 ]
Hu, JH [1 ]
Fu, SK [1 ]
机构：
[1] Fudan Univ, Key Lab Mol Engn Polymers, Educ Minist, Dept Macromol Sci, Shanghai 200433, Peoples R China
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2005年 / 295卷 / 1-2期
关键词：
chitosan; ammonium glycyrrhizinate; nanoparticles;
D O I：
10.1016/j.ijpharm.2005.01.042
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The ammonium glycyrrhizinate-loaded chitosan nanoparticles were prepared by ionic gelation of chitosan with tripolyphosphate anions (TPP). The particle size and zeta potential of nanoparticles were determined, respectively, by dynamic light scattering (DLS) and a zeta potential analyzer. The effects, including chitosan molecular weight, chitosan concentration, ammonium glycyrrhizinate concentration and polyethylene glycol (PEG) on the physicochemical properties of the nanoparticles were studied. These nanoparticles have ammonium glycyrrhizinate loading efficiency. The encapsulation efficiency decreased with the increase of ammonium glycyrrhizinate concentration and chitosan concentration. The introduction of PEG can decrease significantly the Positive charge of particle surface. These studies showed that chitosan can complex TPP to form stable cationic nanoparticles for subsequent ammonium glycyrrhizinate loading, (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码：235 / 245
页数：11
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