Introduction Sex workers face many barriers to accessing the inalienable human right of mental health. The aim of this review was to synthesize the evidence on the barriers to mental healthcare for sex workers and the factors that facilitate uptake. Methods A search conducted in 2018 of peer-reviewed and gray literature produced between 2008 and 2018 in OECD countries resulted in 32 documents eligible for inclusion. Results The literature revealed that the barriers of stigma, discrimination, violence, pathologization, and criminalization exacerbate the psychological distress of sex workers while impeding uptake of mental healthcare. Personal resilience, protective factors, agency, and social inclusion offset these barriers. Conclusions Despite the risk of pervasive mental illness among sex workers due to, primarily, external factors, few studies present comprehensive examinations of sex workers' mental health and fewer still explore sex workers with gender identities and sexual orientations that are not cisgender, heterosexual, or female.