Poly(2-oxazolines) in biological and biomedical application contexts

被引：429

作者：

Adams, Nico ^{[2
]}

Schubert, Ulrich S. ^{[1
,3
,4
]}

机构：

[1] Eindhoven Univ Technol, Lab Macromol Chem & Nanosci, NL-5600 MB Eindhoven, Netherlands

[2] Univ Cambridge, Univ Chem Lab, Unilever Ctr Mol Sci Informat, Cambridge CB1 9SB, England

[3] Dutch Polymer Inst, NL-5612 AB Eindhoven, Netherlands

[4] Univ Jena, Lab Organ & Macromol Chem, D-07743 Jena, Germany

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2007年 / 59卷 / 15期

关键词：

polyoxazoline; biomaterials; self-assembly; drug delivery; gene delivery; stimuli-responsive polymers;

D O I：

10.1016/j.addr.2007.08.018

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Polyoxazolines of various architectures and chemical functionalities can be prepared in a living and therefore controlled manner via cationic ring-opening polymerisation. They have found widespread applications, ranging from coatings to pigment dispersants. Furthermore, several polyoxazolines are water-soluble or amphiphilic and relatively non-toxic, which makes them interesting as biomaterials. This paper reviews the development of polyoxazoline-based polymers in biological and biomedical application contexts since the beginning of the millennium. This includes nanoscalar systems such as membranes and nanoparticles, drug and gene delivery applications, as well as stimuli-responsive systems. (c) 2007 Published by Elsevier B.V.

引用

页码：1504 / 1520

页数：17

共 157 条

[1] A powerful nonviral vector for in vivo gene transfer into the adult mammalian brain: Polyethylenimine [J].