The role of long non-coding RNA H19 in musculoskeletal system: A new player in an old game

被引：26
作者：
Liu, Yang [1 ]
Li, Gang [1 ,2 ,3 ,4 ]
Zhang, Jin-fang [1 ,2 ]
机构：
[1] Chinese Univ Hong Kong, Prince Wales Hosp, Fac Med, Dept Orthopaed & Traumatol, Hong Kong, Hong Kong, Peoples R China
[2] Chinese Univ Hong Kong, Prince Wales Hosp, Li Ka Shing Inst Hlth Sci, Stem Cells & Regenerat Med Lab,Lui Che Woo Inst I, Hong Kong, Hong Kong, Peoples R China
[3] Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Key Lab Regenerat Med,Minist Educ, Hong Kong, Hong Kong, Peoples R China
[4] Chinese Univ Hong Kong, Shenzhen Res Inst, CUHK ACC Space Med Ctr Hlth Maintenance Musculosk, Shenzhen, Peoples R China
来源：
EXPERIMENTAL CELL RESEARCH | 2017年 / 360卷 / 02期
关键词：
Long non-coding RNA; H19; Cellular differentiation; Musculoskeletal system; IMPRINTED GENE NETWORK; TENOGENIC DIFFERENTIATION; MESSENGER-RNA; EXPRESSION; PROMOTES; METASTASIS; MECHANISMS; MICRORNAS; LINCRNA; MIR-675;
D O I：
10.1016/j.yexcr.2017.09.007
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The long non-coding RNAs (IncRNAs) have gained much attention due to its essential roles in molecular regulation. As one of the classic lncRNAs, H19 is strongly expressed during embryogenesis and plays a crucial biological function during development. Mesenchymal stem cells (MSCs) are an ideal cell source for tissue engineering in musculoskeletal system as they own the multi-differentiation ability towards osteogenesis, adipogenesis, tenogenesis or chondrogenesis. In recent years, many studies have been found in the field of H19 mediated cellular differentiation of MSCs. Here, we summarized the current understanding of H19 during multi differentiation of MSCs and its application in tissue regeneration of musculoskeletal system. Particularly, its molecular regulation and biological function during the multi-differentiation were also discussed.
引用
收藏
页码：61 / 65
页数：5
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