Management of antiplatelet therapy in patients undergoing neuroendovascular procedures

被引：91

作者：

Kim, Keri S. ^{[1
]}

Fraser, Justin F. ^{[2
,3
,4
,5
]}

Grupke, Stephen ^{[6
]}

Cook, Aaron M. ^{[7
,8
]}

机构：

[1] Univ Illinois, Med Ctr, Dept Pharm Practice, Chicago, IL USA

[2] UK HealthCare, Ctr Adv Translat Stroke Sci, Dept Neurol Surg, Lexington, KY USA

[3] UK HealthCare, Ctr Adv Translat Stroke Sci, Dept Neurol, Lexington, KY USA

[4] UK HealthCare, Ctr Adv Translat Stroke Sci, Dept Radiol, Lexington, KY USA

[5] UK HealthCare, Ctr Adv Translat Stroke Sci, Dept Anat & Neurobiol, Lexington, KY USA

[6] UK HealthCare, Dept Neurol Surg, Lexington, KY USA

[7] UK HealthCare, 800 Rose St,H110, Lexington, KY 40536 USA

[8] Univ Kentucky, Coll Pharm, Lexington, KY USA

来源：

JOURNAL OF NEUROSURGERY | 2018年 / 129卷 / 04期

关键词：

aneurysm; clopidogrel; intracranial stenosis; platelet reactivity; vascular disorders; TREATMENT PLATELET REACTIVITY; IMPLEMENTATION CONSORTIUM GUIDELINES; PERCUTANEOUS CORONARY INTERVENTION; PIPELINE EMBOLIZATION DEVICE; INTRACRANIAL ANEURYSMS; COIL EMBOLIZATION; NEUROINTERVENTIONAL PROCEDURES; THROMBOEMBOLIC COMPLICATIONS; ENDOVASCULAR TREATMENT; CYP2C19; GENOTYPE;

D O I：

10.3171/2017.5.JNS162307

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Neuroendovascular techniques for treating cerebral aneurysms and other cerebrovascular pathology are increasingly becoming the standard of care. Intraluminal stents, aneurysm coils, and other flow diversion devices typically require concomitant antiplatelet therapy to reduce thromboembolic complications. The variability inherent with the pharmacodynamic response to common antiplatelet agents such as aspirin and clopidogrel complicates optimal selection of antiplatelet agents by clinicians. This review serves to discuss the literature related to antiplatelet use in neuroendovascular procedures and provides recommendations for clinicians on how to approach patients with variable response to antiplatelet agents, particularly clopidogrel.

引用

页码：890 / 905

页数：16

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