Microwave-Assisted, Efficient and Eco-friendly Synthesis of Novel 3H-Benzo[b][1,4]diazepine Derivatives Using Basic Alumina as a Reusable Catalyst

New and facile eco-friendly approach for the synthesis of novel substituted 3H-benzo[b][1,4]diazepine derivatives using non-toxic basic alumina as a reusable catalyst under microwave irradiations is presented for the first time. The influence of different types of alumina as catalyst was studied. It was found that the best yield of the product was obtained with basic alumina catalyst. The best yield of the desired product was achieved using 1 mol% of the catalyst. The procedure resulted in high yields of the product, short reaction duration; operational simplicity, solvent free condition, high atom-economy and low E-factor are the salient features of the present method.