The number of Dopaminergic cells is increased in the olfactory bulb of monkeys chronically exposed to MPTP

被引：28

作者：

Belzunegui, Silvia

Sebastian, Waldy San

Garrido-Gil, Pablo

Izal-Azcarate, Amaya

Vazquez-Claverie, Marianne

Lopez, Berta

Marcilla, Irene

Lanciego, Jose Luis

Luquin, Maria Rosario

机构：

[1] Univ Navarra, Ctr Appl Med Res, Dept Neurosci, Lab Regenerat Therapy, Pamplona 31008, Spain

[2] Univ Navarra, Ctr Appl Med Res, Dept Neurosci, Neuromorphol Tracing Lab, Pamplona 31008, Spain

来源：

SYNAPSE | 2007年 / 61卷 / 12期

关键词：

monkey; MPTP; Parkinson's disease; dopaminergic cells; olfactory bulb;

D O I：

10.1002/syn.20451

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated the impact of the nigrostriatal lesion on the olfactory tyrosine hydroxylase-immunoreactive (TH-ir) cells in monkeys. The majority of these TH-ir cells appeared in the glomerular layer of the olfactory bulb and many were immature but functional dopaminergic neurons. In parkinsonian monkeys the number of olfactory dopaminergic neurons increased up to 100% as compared to controls, but their phenotype did not change. This increased TH-ir cell population might be a direct consequence of the nigral cell loss and contribute to the hyposmia reported by Parkinson's disease patients.

引用

页码：1006 / 1012

页数：7

共 28 条

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[22] Selegiline normalizes, while L-DOPA sustains the increased number of dopamine neurons in the olfactory bulb in a 6-OHDA mouse model of Parkinson's disease
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