Anti-Influenza Virus Compound from Streptomyces sp RI18

被引：18

作者：

Takagi, Motoki ^{[1
]}

Motohashi, Keiichiro ^{[1
]}

Nagai, Aya ^{[1
]}

Izumikawa, Miho ^{[1
]}

Tanaka, Masahiro ^{[1
]}

Fuse, Shinichiro ^{[2
]}

Doi, Takayuki ^{[3
]}

Iwase, Keiichiro ^{[4
]}

Kawaguchi, Atsushi ^{[4
,5
]}

Nagata, Kyosuke ^{[4
]}

Takahashi, Takashi ^{[2
]}

Shin-ya, Kazuo ^{[6
]}

机构：

[1] JBIC, BIRC, Koto Ku, Tokyo 1350064, Japan

[2] Tokyo Inst Technol, Dept Appl Chem, Meguro Ku, Tokyo 1528552, Japan

[3] Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan

[4] Univ Tsukuba, Dept Infect Biol, Grad Sch Comprehens Human Sci, Tsukuba, Ibaraki 3058575, Japan

[5] Kitasato Univ, Kitasato Inst Life Sci, Minato Ku, Tokyo 1088641, Japan

[6] Natl Inst Adv Ind Sci & Technol, BRIC, Koto Ku, Tokyo 1350064, Japan

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 20期

基金：

日本学术振兴会;

关键词：

INFLUENZA VACCINE; INFECTION; FR-900848; HUMANS; DRIFT;

D O I：

10.1021/ol102007d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Screening for anti-influenza virus activity in compounds isolated from Streptomyces sp RI18, which was isolated using the membrane filter method, uncovered a novel compound, JBIR-68 (1), which contains a unique skeleton. Its structure was established by extensive NMR and MS analyses. In addition, 1 was synthesized to confirm the configuration of its sugar moiety. Compound 1 inhibited influenza virus growth in plaque assays.

引用

页码：4664 / 4666

页数：3

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