A Copper(I) Platform for One-Pot P-H Bond Formation and Hydrophosphination of Heterocumulenes

被引：12

作者：

Downie, Thomas M. Horsley ^{[1
]}

Mahon, Mary F. ^{[1
]}

Lowe, John P. ^{[1
]}

Bailey, Rowan M. ^{[1
]}

Liptrot, David J. ^{[1
]}

机构：

[1] Univ Bath, Dept Chem, Bath BA2 7AY, England

来源：

ACS CATALYSIS | 2022年 / 12卷 / 14期

基金：

英国工程与自然科学研究理事会;

关键词：

phosphine; P-H bond formation; hydrophosphination; heterocumulene; copper catalysis; homogeneous catalysis; PHOSPHORORGANISCHE VERBINDUNGEN; CONVENIENT SYNTHESIS; PHOSPHINE OXIDES; REDUCTION; SECONDARY; TERTIARY; VERSATILE; ELEMENTS; ALKENES;

D O I：

10.1021/acscatal.2c02199

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The reaction of phosphorus(III) esters with pinacolborane generates phosphines via the action of an NHC-copper(I) catalyst. This gives access, within minutes, to 12 P-H bonded species, including secondary and primary phosphines as well as PH3, in excellent conversions. These phosphines can be subsequently applied in the copper(I)-catalyzed hydrophosphination of heterocumulenes in a telescoped, one-pot fashion. This approach yielded 12 phosphaureas, 3 phosphaguanidines, and 2 phosphathioureas in moderate to excellent yields without the need to handle toxic, pyrophoric, or gaseous P-H bond containing compounds. The crystal structures of two of the phosphaureas, PhP(C(O)NHPh)(2) and P(C(O)NHPh)(3), are presented.

引用

页码：8214 / 8219

页数：6

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