A surface plasmon resonance array biosensor based on spectroscopic imaging

被引：64
作者：
O'Brien, MJ
Pérez-Luna, VH
Brueck, SRJ
López, GP [1 ]
机构：
[1] Univ New Mexico, Dept Phys & Astron, Ctr High Technol Mat, Albuquerque, NM 87131 USA
[2] Univ New Mexico, Dept Chem & Nucl Engn, Farris Engn Ctr 209, Albuquerque, NM 87131 USA
来源：
BIOSENSORS & BIOELECTRONICS | 2001年 / 16卷 / 1-2期
基金：
美国国家科学基金会;
关键词：
surface plasmon; array; multianalyte; cross-reactive; biosensor; microfluidic;
D O I：
10.1016/S0956-5663(00)00137-8
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
We have developed a multi-element transduction system which combines conventional SPR spectroscopy with one-dimensional SPR microscopy to create an effective platform for monitoring binding events on macro- or micro-patterned receptor arrays created on disposable sensor chips. This creates an effective platform for monitoring simultaneous binding events on each of the regions patterned with the receptors. This system has been specifically designed with commercially available components to allow relatively easy duplication. Furthermore. this system can use a proven, simple method to compensate for changes in the bulk index of refraction of the solution containing the analytes due to changes in temperature or solute concentration with simple modifications to the sensor chips alone. Preliminary results demonstrate how this system can be used to monitor several independent biospecific binding events simultaneously. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：97 / 108
页数：12
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