Circulating microRNAs as Promising Tumor Biomarkers

被引：29

作者：

Chen, Meng ^{[1
]}

Calin, George A. ^{[2
]}

Meng, Qing H. ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Lab Med, Div Pathol & Lab Med, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Div Canc Med, Houston, TX 77030 USA

来源：

ADVANCES IN CLINICAL CHEMISTRY, VOL 67 | 2014年 / 67卷

关键词：

METASTATIC BREAST-CANCER; BLOOD-BASED MARKERS; DOWN-REGULATION; POTENTIAL BIOMARKERS; COLORECTAL-CANCER; PLASMA MICRORNAS; SMALL RNA; DIAGNOSTIC-MARKER; MIRNA BIOMARKERS; PROGNOSTIC VALUE;

D O I：

10.1016/bs.acc.2014.09.007

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

microRNAs (miRNAs) are small, nonprotein-coding RNAs that function as posttranscriptional regulators of target genes. miRNAs are involved in multiple cell differentiation, proliferation, and apoptosis processes that are closely related to tumorigenesis. Circulating miRNAs are promising cancer biomarkers under development with great translational potential in personalized medicine. Here, we describe the origin and function of circulating miRNAs and compare the current new high-throughput technology applied to miRNA quantitation. The latest publications on circulating miRNAs were summarized, indicating that miRNAs are potential biomarkers of diagnosis, prognosis, and treatment response of major cancer types including prostate, breast, lung, colorectal, and hematological cancers. We addressed the strengths and limitations of applying circulating miRNAs in clinical laboratory and several issues associated with the accurate measurement of circulating miRNAs.

引用

页码：189 / 214

页数：26

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