Hybrid Mesoporous Silica Nanoparticles Grafted with 2-(tert-butylamino)ethyl Methacrylate-b-poly(ethylene Glycol) Methyl Ether Methacrylate Diblock Brushes as Drug Nanocarrier

被引：37

作者：

Alswieleh, Abdullah M. ^{[1
]}

Beagan, Abeer M. ^{[1
]}

Alsheheri, Bayan M. ^{[1
]}

Alotaibi, Khalid M. ^{[1
]}

Alharthi, Mansour D. ^{[1
]}

Almeataq, Mohammed S. ^{[2
]}

机构：

[1] King Saud Univ, Coll Sci, Dept Chem, Riyadh 11451, Saudi Arabia

[2] King Abdulaziz City Sci & Techenol, Riyadh 11451, Saudi Arabia

来源：

MOLECULES | 2020年 / 25卷 / 01期

关键词：

mesoporous silica nanoparticles; polymer brushes; pH responsive polymer; surface-initiated atom transfer radical polymerization; POLYMER BRUSHES; RADICAL POLYMERIZATION; BIOCOMPATIBILITY; PARTICLES; BEHAVIOR; THERMO;

D O I：

10.3390/molecules25010195

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This paper introduces the synthesis of well-defined 2-(tert-butylamino)ethyl methacrylate-b-poly(ethylene glycol) methyl ether methacrylate diblock copolymer, which has been grafted onto mesoporous silica nanoparticles (PTBAEMA-b-PEGMEMA-MSNs) via atom transfer radical polymerization (ATRP). The ATRP initiators were first attached to the MSN surfaces, followed by the ATRP of 2-(tert-butylamino)ethyl methacrylate (PTBAEMA). CuBr2/bipy and ascorbic acid were employed as the catalyst and reducing agent, respectively, to grow a second polymer, poly(ethylene glycol) methyl ether methacrylate (PEGMEMA). The surface structures of these fabricated nanomaterials were then analyzed using Fourier Transform Infrared (FTIR) spectroscopy. The results of Thermogravimetric Analysis (TGA) show that ATRP could provide a high surface grafting density for polymers. Dynamic Light Scattering (DLS) was conducted to investigate the pH-responsive behavior of the diblock copolymer chains on the nanoparticle surface. In addition, multifunctional pH-sensitive PTBAEMA-b-PEGMEMA-MSNs were loaded with doxycycline (Doxy) to study their capacities and long-circulation time.

引用

页数：12