Prenatal Maternal Stress and the Risk of Asthma in Children

被引：35

作者：

Douros, Konstantinos ^{[1
]}

Moustaki, Maria ^{[2
]}

Tsabouri, Sophia ^{[3
]}

Papadopoulou, Anna ^{[1
]}

Papadopoulos, Marios ^{[1
]}

Priftis, Kostas N. ^{[1
]}

机构：

[1] Natl & Kapodistrian Univ Athens, Sch Med, Attikon Univ Gen Hosp, Dept Pediat 3, Athens, Greece

[2] Aghia Sophia Childrens Hosp, Cyst Fibrosis Dept, Athens, Greece

[3] Univ Ioannina, Sch Med, Dept Paediat, Ioannina, Greece

来源：

FRONTIERS IN PEDIATRICS | 2017年 / 5卷

关键词：

maternal prenatal stress; offspring; wheezing; asthma; glucocorticoids; microbiota; FETAL-GROWTH RESTRICTION; EARLY-LIFE; PSYCHOSOCIAL STRESS; GUT-MICROBIOTA; PSYCHOLOGICAL STRESS; PLACENTAL-TRANSFER; CHILDHOOD ASTHMA; ATOPIC DISEASES; IMMUNE FUNCTION; PRETERM BIRTH;

D O I：

10.3389/fped.2017.00202

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Emerging evidence indicate that maternal prenatal stress (MPS) can result in a range of long-term adverse effects in the offspring. The underlying mechanism of MPS is not fully understood. However, its complexity is emphasized by the number of purportedly involved pathways namely, placental deregulated metabolism of maternal steroids, impaired maturation of fetal HPA axis, imbalanced efflux of commensal bacteria across the placenta, and skewed immune development toward Th2. Fetal programming probably exerts a pivotal role in the end result of the above pathways through the modulation of gene expression. In this review, we highlight the current knowledge from epidemiological and experimental studies regarding the effects of MPS on asthma development in the offspring.

引用

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