SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF 2,9-DISUBSTITUTED IMIDAZO[1,2-a]BENZIMIDAZOLE PHENYL- AND ALKYLTHIOCARBAMIDES

被引：4

作者：

Anisimova, V. A. ^{[1
]}

Zhukovskaya, O. N. ^{[1
]}

Spasov, A. A. ^{[2
,3
,4
]}

Kuznetsova, V. A. ^{[2
,3
]}

Kosolapov, V. A. ^{[2
,3
]}

Yakovlev, D. S. ^{[2
,4
]}

Solov'eva, O. A. ^{[2
]}

Sorotskii, D. V. ^{[3
]}

Brigadirova, A. A. ^{[2
]}

Vorob'ev, E. S. ^{[2
]}

机构：

[1] Southern Fed Univ, Inst Phys & Organ Chem, Rostov Na Donu 344090, Russia

[2] Volgograd State Med Univ, Volgograd 400131, Russia

[3] Volgograd State Med Univ, Res Inst Pharmacol, Volgograd 400131, Russia

[4] Volgograd State Med Univ, Volgograd Med Sci Ctr, Volgograd 400131, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2016年 / 49卷 / 10期

关键词：

2,9-disubstituted imidazo[1,2-a]benzimidazole-3-thiocarbamides; synthesis; 5-HT4-agonist effect; AT(1)-antagonist activity; antioxidant properties; antiglycation activity; SULFORAPHANE;

D O I：

10.1007/s11094-016-1346-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of phenyl- and alkylthiocarbamides were synthesized by the reaction of 2,9-disubstituted imidazo-[1,2-a]benzimidazoles with phenyl- and alkylisothiocyanates. The structures of the products were confirmed by elemental analysis and PMR spectroscopy. Some of the synthesized compounds were capable of inhibiting non-enzymatic glycosylation of proteins. The concentration dependences of the antiglycation effect of the most active substances and aminoguanidine were studied.

引用

页码：653 / 656

页数：4

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