Potential Role of Oxidative Stress in Ocular Surface Inflammation and Dry Eye Disease

被引：188

作者：

Dogru, Murat ^{[1
]}

Kojima, Takashi ^{[1
]}

Simsek, Cem ^{[1
]}

Tsubota, Kazuo ^{[1
]}

机构：

[1] Keio Univ, Sch Med, Dept Ophthalmol, Tokyo, Japan

来源：

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | 2018年 / 59卷 / 14期

关键词：

oxidative stress; reactive oxygen species; dry eye; CONJUNCTIVAL EPITHELIUM; SUPEROXIDE-DISMUTASE; RHEUMATOID-ARTHRITIS; ANTIOXIDANT THERAPY; LACRIMAL GLAND; EXPRESSION; THIOREDOXIN; DYSFUNCTION; KNOCKOUT; DAMAGE;

D O I：

10.1167/iovs.17-23402

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Reactive oxygen species (ROS) are produced as a by-product during the mitochondrial respiration of the oxygen and potentially able to damage the tissues. Oxidative stress occurs as a result of the disruption of the balance between the anti-oxidant system and the pro-oxidant system found in cells. It has been accepted that overexpression of ROS can be induced in the ocular surface as a result of many acute and chronic diseases and even in normal aging. Recent studies demonstrated that oxidative stress damages the ocular surface and plays an important role in the mechanism of dry eye disease. There is a need to investigate the therapeutic modalities employing topical/systemic use of antioxidants in dry eye disease. This review will summarize the recent studies showing the important relationship between oxidative stress and dry eye disease.

引用

页码：DES163 / DES168

页数：6

共 43 条

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