A novel ion selective PVC membrane electrode for determination of propranolol in pharmaceutical formulation

A novel ion selective PVC membrane electrode for determination of propranolol is developed. Silicotungstic acid is used as the counter ion and diisononyl phthalate (DNP) used as the plastizer. The electrode exhibits excellent potential response properties, showing a Nernstian response in the concentration of 3.0 x 10(-6) similar to 2.6 x 10(-2) M with the slope of 54.7 mV per decade, shorter conditioning time (similar to 3 h), fast response time (40 s), a lower limit of detection (1.0 x 10(-7) M). The electrode is successfully used for the analysis of propranolol in pharmaceutical formulation with the recoveries of 99.2 similar to 102.6 %, by using a direct potentiometric method and which does not require tedious sample preparation.