Adipose Stem Cell Translational Applications: From Bench-to-Bedside

被引：77

作者：

Argentati, Chiara ^{[1
]}

Morena, Francesco ^{[1
]}

Bazzucchi, Martina ^{[1
]}

Armentano, Ilaria ^{[2
]}

Emiliani, Carla ^{[1
,3
]}

Martino, Sabata ^{[1
,3
]}

机构：

[1] Univ Perugia, Dept Chem Biol & Biotechnol, Via Giochetto, I-06126 Perugia, Italy

[2] Tuscia Univ, Dept Ecol & Biol Sci, Largo Univ Snc, I-01100 Viterbo, Italy

[3] Ctr Excellence Nanostruct Innovat Mat, CEMIN, Via Giochetto, I-06126 Perugia, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 11期

关键词：

regenerative medicine; gene/cell therapy; biomaterials; tissue engineering; STROMAL-VASCULAR FRACTION; ENHANCED OSTEOGENIC DIFFERENTIATION; HUMAN BONE-MARROW; GENE-THERAPY; MYOGENIC DIFFERENTIATION; EXTRACELLULAR-MATRIX; MURINE MODEL; METACHROMATIC LEUKODYSTROPHY; IMMUNOSUPPRESSIVE PROPERTIES; NEUROGENIC DIFFERENTIATION;

D O I：

10.3390/ijms19113475

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

During the last five years, there has been a significantly increasing interest in adult adipose stem cells (ASCs) as a suitable tool for translational medicine applications. The abundant and renewable source of ASCs and the relatively simple procedure for cell isolation are only some of the reasons for this success. Here, we document the advances in the biology and in the innovative biotechnological applications of ASCs. We discuss how the multipotential property boosts ASCs toward mesenchymal and non-mesenchymal differentiation cell lineages and how their character is maintained even if they are combined with gene delivery systems and/or biomaterials, both in vitro and in vivo.

引用

页数：36

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