Adipose Stem Cell Translational Applications: From Bench-to-Bedside

被引：77

作者：

Argentati, Chiara ^{[1
]}

Morena, Francesco ^{[1
]}

Bazzucchi, Martina ^{[1
]}

Armentano, Ilaria ^{[2
]}

Emiliani, Carla ^{[1
,3
]}

Martino, Sabata ^{[1
,3
]}

机构：

[1] Univ Perugia, Dept Chem Biol & Biotechnol, Via Giochetto, I-06126 Perugia, Italy

[2] Tuscia Univ, Dept Ecol & Biol Sci, Largo Univ Snc, I-01100 Viterbo, Italy

[3] Ctr Excellence Nanostruct Innovat Mat, CEMIN, Via Giochetto, I-06126 Perugia, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 11期

关键词：

regenerative medicine; gene/cell therapy; biomaterials; tissue engineering; STROMAL-VASCULAR FRACTION; ENHANCED OSTEOGENIC DIFFERENTIATION; HUMAN BONE-MARROW; GENE-THERAPY; MYOGENIC DIFFERENTIATION; EXTRACELLULAR-MATRIX; MURINE MODEL; METACHROMATIC LEUKODYSTROPHY; IMMUNOSUPPRESSIVE PROPERTIES; NEUROGENIC DIFFERENTIATION;

D O I：

10.3390/ijms19113475

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

During the last five years, there has been a significantly increasing interest in adult adipose stem cells (ASCs) as a suitable tool for translational medicine applications. The abundant and renewable source of ASCs and the relatively simple procedure for cell isolation are only some of the reasons for this success. Here, we document the advances in the biology and in the innovative biotechnological applications of ASCs. We discuss how the multipotential property boosts ASCs toward mesenchymal and non-mesenchymal differentiation cell lineages and how their character is maintained even if they are combined with gene delivery systems and/or biomaterials, both in vitro and in vivo.

引用

页数：36

共 315 条

[1] Comparative Immunophenotypic Characteristics, Proliferative Features, and Osteogenic Differentiation of Stem Cells Isolated from Human Permanent and Deciduous Teeth with Bone Marrow [J].

Aghajani, Farzaneh ;

Hooshmand, Tabassom ;

Khanmohammadi, Manijeh ;

Khanjani, Sayeh ;

Edalatkhah, Haleh ;

Zarnani, Amir-Hassan ;

Kazemnejad, Somaieh .

MOLECULAR BIOTECHNOLOGY, 2016, 58 (06) :415-427

[2] Gene therapy for ADA-SCID, the first marketing approval of an ex vivo gene therapy in Europe: paving the road for the next generation of advanced therapy medicinal products [J].

Aiuti, Alessandro ;

Roncarolo, Maria Grazia ;

Naldini, Luigi .

EMBO MOLECULAR MEDICINE, 2017, 9 (06) :737-740

[3] Alpha-1 Antitrypsin Gene Therapy Ameliorates Bone Loss in Ovariectomy-Induced Osteoporosis Mouse Model [J].

Akbar, Mohammad Ahsanul ;

Cao, Jay J. ;

Lu, Yuanqing ;

Nardo, David ;

Chen, Mong-Jen ;

Elshikha, Ahmed S. ;

Ahamed, Rubina ;

Brantly, Mark ;

Holliday, L. Shannon ;

Song, Sihong .

HUMAN GENE THERAPY, 2016, 27 (09) :679-686

[4]

Albertsson AC, 2002, ADV POLYM SCI, V157, P1

[5]

Alenzi Faris Q, 2010, Lab Hematol, V16, P53, DOI 10.1532/LH96.10010

[6] Complete regression of glioblastoma by mesenchymal stem cells mediated prodrug gene therapy simulating clinical therapeutic scenario [J].

Altaner, Cestmir ;

Altanerova, Veronika ;

Cihova, Marina ;

Ondicova, Katarina ;

Rychly, Boris ;

Baciak, Ladislav ;

Mravec, Boris .

INTERNATIONAL JOURNAL OF CANCER, 2014, 134 (06) :1458-1465

[7] Prodrug suicide gene therapy for cancer targeted intracellular by mesenchymal stem cell exosomes [J].

Altanerova, Ursula ;

Jakubechova, Jana ;

Benejova, Katarina ;

Priscakova, Petra ;

Pesta, Martin ;

Pitule, Pavel ;

Topolcan, Ondrej ;

Kausitz, Juraj ;

Zduriencikova, Martina ;

Repiska, Vanda ;

Altaner, Cestmir .

INTERNATIONAL JOURNAL OF CANCER, 2019, 144 (04) :897-908

[8] Human Tissue-Resident Stem Cells Combined with Hyaluronic Acid Gel Provide Fibrovascular-Integrated Soft-Tissue Augmentation in a Murine Photoaged Skin Model [J].

Altman, Andrew M. ;

Khalek, Feras J. Abdul ;

Seidensticker, Max ;

Pinilla, Severin ;

Yan, Yasheng ;

Coleman, Micheal ;

Song, Yao-Hua ;

Butler, Charles E. ;

Alt, Eckhard U. .

PLASTIC AND RECONSTRUCTIVE SURGERY, 2010, 125 (01) :63-73

[9] Hyaluronic acid facilitates chondrogenesis and matrix deposition of human adipose derived mesenchymal stem cells and human chondrocytes co-cultures [J].

Amann, Elisabeth ;

Wolff, Paul ;

Breel, Ernst ;

van Griensven, Martijn ;

Balmayor, Elizabeth R. .

ACTA BIOMATERIALIA, 2017, 52 :130-144

[10] Different Porosities of Chitosan Can Influence the Osteogenic Differentiation Potential of Stem Cells [J].

Ardeshirylajimi, Abdolreza ;

Delgoshaie, Mahdieh ;

Mirzaei, Samaneh ;

Khojasteh, Arash .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2018, 119 (01) :625-633

← 1 2 3 4 5 6 7 8 9 10 →