Associations of prostate cancer risk variants with disease aggressiveness: results of the NCI-SPORE Genetics Working Group analysis of 18,343 cases

被引：42

作者：

Helfand, Brian T. ^{[1
]}

Roehl, Kimberly A. ^{[2
]}

Cooper, Phillip R. ^{[2
]}

McGuire, Barry B. ^{[2
]}

Fitzgerald, Liesel M. ^{[3
]}

Cancel-Tassin, Geraldine ^{[4
]}

Cornu, Jean-Nicolas ^{[4
]}

Bauer, Scott ^{[5
]}

Blarigan, Erin L. Van ^{[5
]}

Chen, Xin ^{[6
]}

Duggan, David ^{[7
]}

Ostrander, Elaine A. ^{[8
]}

Gwo-Shu, Mary ^{[9
]}

Zhang, Zuo-Feng ^{[10
]}

Chang, Shen-Chih ^{[10
]}

Jeong, Somee ^{[10
]}

Fontham, Elizabeth T. H. ^{[11
]}

Smith, Gary ^{[12
]}

Mohler, James L. ^{[12
]}

Berndt, Sonja I. ^{[13
]}

McDonnell, Shannon K. ^{[14
]}

Kittles, Rick ^{[15
]}

Rybicki, Benjamin A. ^{[16
]}

Freedman, Matthew ^{[17
]}

Kantoff, Philip W. ^{[17
]}

Pomerantz, Mark ^{[18
]}

Breyer, Joan P. ^{[19
]}

Smith, Jeffrey R. ^{[19
]}

Rebbeck, Timothy R. ^{[20
]}

Mercola, Dan ^{[6
]}

Isaacs, William B. ^{[21
]}

Wiklund, Fredrick ^{[22
]}

Cussenot, Olivier ^{[4
]}

Thibodeau, Stephen N. ^{[23
]}

Schaid, Daniel J. ^{[14
]}

Cannon-Albright, Lisa ^{[24
]}

Cooney, Kathleen A. ^{[25
]}

Chanock, Stephen J. ^{[26
]}

Stanford, Janet L. ^{[27
]}

Chan, June M. ^{[5
]}

Witte, John ^{[5
]}

Xu, Jianfeng ^{[28
]}

Bensen, Jeannette T. ^{[29
]}

Taylor, Jack A. ^{[30
]}

Catalona, William J. ^{[2
]}

机构：

[1] NorthShore Univ Hlth Syst, Div Urol, Dept Surg, John & Carol Walter Ctr Urol Hlth, Evanston, IL USA

[2] NW Univ Feinberg Sch Med, Dept Urol, Chicago, IL USA

[3] Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic 3004, Australia

[4] Assistance Publ Hopitaux Paris, CeRePP ICPCG Grp, Hop Tenon, F-75020 Paris, France

[5] Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, Genome Anal Core Facil, San Francisco, CA USA

[6] Univ Calif Irvine, Dept Pathol & Lab Med, Irvine, CA USA

[7] Integrated Canc Genom Div, TGen, Phoenix, AZ USA

[8] Natl Human Genome Res Inst, Canc Genet Branch, Bethesda, MD USA

[9] Dana Farber Canc Inst & Harvard Med Sch, Dept Med Oncol, Boston, MA USA

[10] Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA USA

[11] Louisiana State Univ Hlth Sci Ctr, Sch Publ Hlth, New Orleans, LA USA

[12] Roswell Pk Canc Inst, Dept Urol, Buffalo, NY USA

[13] Natl Canc Inst, Div Canc Epidemiol & Genet, Occupat & Environm Epidemiol Branch, Bethesda, MD USA

[14] Dept Hlth Sci Res, Mayo Clin, Rochester, MN USA

[15] Univ Arizona, Div Urol, Dept Surg, Tucson, AZ USA

[16] Dept Publ Hlth Sci, Henry Ford Hlth Syst, Detroit, MI USA

[17] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA USA

[18] Dana Farber Canc Inst & Harvard Med Sch, Lank Ctr Genitourinary Oncol, Boston, MA USA

[19] Vanderbilt Univ Sch Med, Dept Med, Vanderbilt Ingram Canc Ctr, Nashville, TN USA

[20] Univ Pennsylvania Sch Med, Dept Biostatist & Epidemiol, Ctr Clin Epidemiol & Biostatist, Philadelphia, PA USA

[21] Johns Hopkins Univ, Dept Urol, Baltimore, MD USA

[22] Univ UmeAyen ICPCG Grp, UmeAyen, Sweden

[23] Dept Lab Med & Pathol, Mayo Clin, Rochester, MN USA

[24] Univ Utah Sch Med, Div Genet Epidemiol, Dept Med, Salt Lake City, UT USA

[25] Univ Michigan Med Sch, Dept Urol, Dept Internal Med, Ann Arbor, MI USA

[26] Natl Canc Inst, Div Canc Epidemiol & Genet, Rockville, MD USA

[27] Div Publ Hlth Sci, Fred Hutchinson Canc Res Ctr, Seattle, WA USA

[28] NorthShore Univ Hlth Syst, Program Personalized Canc Care & Dept Surg, Evanston, IL USA

[29] Univ N Carolina, Gillings Sch Global Publ Hlth Dept Epidemiol & Li, Chapel Hill, NC USA

[30] Natl Inst Environm Hlth Sci, Epidemiol Branch & Lab Mol Carcinogenesis, Durham, NC USA

来源：

HUMAN GENETICS | 2015年 / 134卷 / 04期

关键词：

GENOME-WIDE ASSOCIATION; SUSCEPTIBILITY LOCI; LINKAGE SCAN; CHROMOSOME; 19Q; GLEASON SCORE; PSA LEVELS; MEN; MORTALITY; POLYMORPHISM; REPLICATION;

D O I：

10.1007/s00439-015-1534-9

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Genetic studies have identified single nucleotide polymorphisms (SNPs) associated with the risk of prostate cancer (PC). It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score (Gleason a parts per thousand currency sign6, 7, a parts per thousand yen8) and aggressiveness (non-aggressive, intermediate, and aggressive disease). Statistical analyses were used to compare the frequency of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 (G) was significantly and inversely associated with aggressive (OR = 0.77; 95 % CI 0.69-0.87) and high-grade disease (OR = 0.77; 95 % CI 0.68-0.86) in European men. Similar associations with aggressive (OR = 0.72; 95 % CI 0.58-0.89) and high-grade disease (OR = 0.69; 95 % CI 0.54-0.87) were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels (< 4.0 ng/mL) in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness.

引用

页码：439 / 450

页数：12

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