Intestinal dysbiosis and innate immune responses in axial spondyloarthritis

被引：24

作者：

Ciccia, Francesco ^{[1
]}

Ferrante, Angelo ^{[1
]}

Triolo, Giovanni ^{[1
]}

机构：

[1] Univ Palermo, Dipartimento Biomed Med Interna & Specialist, Sez Reumatol, Palermo, Italy

来源：

CURRENT OPINION IN RHEUMATOLOGY | 2016年 / 28卷 / 04期

关键词：

dysbiosis; gut inflammation; IL-17; IL-23; IL-9; innate lymphoid cells; spondyloarthritis; UNFOLDED PROTEIN RESPONSE; ANKYLOSING-SPONDYLITIS; PANETH CELLS; GUT; EXPRESSION; INTERLEUKIN-23; PERMEABILITY; MICROBIOTA; AUTOPHAGY;

D O I：

10.1097/BOR.0000000000000296

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of reviewInflammatory innate and adaptive immune cell responses to commensal bacteria underlie the pathogenesis of human chronic inflammatory diseases. Intestinal dysbiosis has been described in patients with spondyloarthritis (SpA) and seems to be correlated with histologic and immunologic alterations. Purpose of this review is to discuss the relationship occurring between intestinal dysbiosis and innate immune responses in patients with axial SpA.Recent findingsIntestinal dysbiosis and differential activation of intestinal immune responses in patients with SpA have been demonstrated. Furthermore, innate cells that appear to be involved in the pathogenesis of SpA may control intestinal homeostasis through induction of apoptotic cell death and deletion of activated commensal bacteria-specific T cells.SummaryAlthough the evidence shows that dysbiosis occurs in SpA, it is not clear the role of dysbiosis in regulating innate immune responses in SpA. Relationships between cause and effect remain to be answered.Video abstracthttp://links.lww.com/COR/A34.

引用

页码：352 / 358

页数：7

共 37 条

[1] Paneth cells as a site of origin for intestinal inflammation [J].

Adolph, Timon E. ;

Tomczak, Michal F. ;

Niederreiter, Lukas ;

Ko, Hyun-Jeong ;

Boeck, Janne ;

Martinez-Naves, Eduardo ;

Glickman, Jonathan N. ;

Tschurtschenthaler, Markus ;

Hartwig, John ;

Hosomi, Shuhei ;

Flak, Magdalena B. ;

Cusick, Jennifer L. ;

Kohno, Kenji ;

Iwawaki, Takao ;

Billmann-Born, Susanne ;

Raine, Tim ;

Bharti, Richa ;

Lucius, Ralph ;

Kweon, Mi-Na ;

Marciniak, Stefan J. ;

Choi, Augustine ;

Hagen, Susan J. ;

Schreiber, Stefan ;

Rosenstiel, Philip ;

Kaser, Arthur ;

Blumberg, Richard S. .

NATURE, 2013, 503 (7475) :272-+

[2] The biology of innate lymphoid cells [J].

Artis, David ;

Spits, Hergen .

NATURE, 2015, 517 (7534) :293-301

[3] The Multifaceted Role of Commensal Microbiota in Homeostasis and Gastrointestinal Diseases [J].

Barbosa Silva, Marcelo Jose ;

Heitor Carneiro, Matheus Batista ;

Pultz, Brunna dos Anjos ;

Silva, Danielle Pereira ;

de Moura Lopes, Mateus Eustaquio ;

dos Santos, Liliane Martins .

JOURNAL OF IMMUNOLOGY RESEARCH, 2015, 2015

[4] GUT DYSBIOSIS IN PATIENTS WITH HLA-B27+ANKYLOSING SPONDYLITIS IS ASSOCIATED WITH ILEITIS, DOWN-REGULATION OF TIGHT JUNCTION PROTEINS, INCREASED SERUM LEVELS OF LPS AND MONOCYTES ANERGY [J].

Ciccia, F. ;

Luchetti, M. M. ;

Guggino, G. ;

Rossini, M. ;

Raimondo, S. ;

Gabrielli, A. ;

Alessandro, R. ;

Rizzo, A. ;

Triolo, G. .

ANNALS OF THE RHEUMATIC DISEASES, 2015, 74 :148-149

[5] Interleukin-9 Overexpression and Th9 Polarization Characterize the Inflamed Gut, the Synovial Tissue, and the Peripheral Blood of Patients With Psoriatic Arthritis [J].

Ciccia, Francesco ;

Guggino, Giuliana ;

Ferrante, Angelo ;

Raimondo, Stefania ;

Bignone, Rodolfo ;

Rodolico, Vito ;

Peralta, Sergio ;

Van Tok, Melissa ;

Cannizzaro, Alessandra ;

Schinocca, Claudia ;

Ruscitti, Piero ;

Cipriani, Paola ;

Giacomelli, Roberto ;

Alessandro, Riccardo ;

Dieli, Francesco ;

Rizzo, Aroldo ;

Baeten, Dominique ;

Triolo, Giovanni .

ARTHRITIS & RHEUMATOLOGY, 2016, 68 (08) :1922-1931

[6] Type 3 innate lymphoid cells producing IL-17 and IL-22 are expanded in the gut, in the peripheral blood, synovial fluid and bone marrow of patients with ankylosing spondylitis [J].

Ciccia, Francesco ;

Guggino, Giuliana ;

Rizzo, Aroldo ;

Saieva, Laura ;

Peralta, Sergio ;

Giardina, AnnaRita ;

Cannizzaro, Alessandra ;

Sireci, Guido ;

De Leo, Giacomo ;

Alessandro, Riccardo ;

Triolo, Giovanni .

ANNALS OF THE RHEUMATIC DISEASES, 2015, 74 (09) :1739-1747

[7] Evidence that autophagy, but not the unfolded protein response, regulates the expression of IL-23 in the gut of patients with ankylosing spondylitis and subclinical gut inflammation [J].

Ciccia, Francesco ;

Accardo-Palumbo, Antonina ;

Rizzo, Aroldo ;

Guggino, Giuliana ;

Raimondo, Stefania ;

Giardina, AnnaRita ;

Cannizzaro, Alessandra ;

Colbert, Robert A. ;

Alessandro, Riccardo ;

Triolo, Giovanni .

ANNALS OF THE RHEUMATIC DISEASES, 2014, 73 (08) :1566-1574

[8] Increased expression of interleukin-32 in the inflamed ileum of ankylosing spondylitis patients [J].

Ciccia, Francesco ;

Rizzo, Aroldo ;

Accardo-Palumbo, Antonina ;

Giardina, AnnaRita ;

Bombardieri, Michele ;

Guggino, Giuliana ;

Taverna, Simona ;

De Leo, Giacomo ;

Alessandro, Riccardo ;

Triolo, Giovanni .

RHEUMATOLOGY, 2012, 51 (11) :1966-1972

[9] Over-expression of paneth cell-derived anti-microbial peptides in the gut of patients with ankylosing spondylitis and subclinical intestinal inflammation [J].

Ciccia, Francesco ;

Bombardieri, Michele ;

Rizzo, Aroldo ;

Principato, Alfonso ;

Giardina, Anna R. ;

Raiata, Francesca ;

Peralta, Sergio ;

Ferrante, Angelo ;

Drago, Sandro ;

Cottone, Mario ;

Pitzalis, Costantino ;

Triolo, Giovanni .

RHEUMATOLOGY, 2010, 49 (11) :2076-2083

[10] Overexpression of Interleukin-23, but Not Interleukin-17, as an Immunologic Signature of Subdinical Intestinal Inflammation in Ankylosing Spondylitis [J].

Ciccia, Francesco ;

Bombardieri, Michele ;

Principato, Alfonso ;

Giardina, AnnaRita ;

Tripodo, Claudio ;

Porcasi, Rossana ;

Peralta, Sergio ;

Franco, Vito ;

Giardina, Ennio ;

Craxi, Antonio ;

Pitzalis, Costantino ;

Triolo, Giovanni .

ARTHRITIS AND RHEUMATISM, 2009, 60 (04) :955-965

← 1 2 3 4 →