Hepatitis B and C viruses and risk of non-Hodgkin lymphoma: a case-control study in Italy

被引:40
|
作者
Taborelli, Martina [1 ]
Polesel, Jerry [1 ]
Montella, Maurizio [2 ]
Libra, Massimo [3 ]
Tedeschi, Rosamaria [4 ]
Battiston, Monica [5 ]
Spina, Michele [6 ]
Di Raimondo, Francesco [7 ]
Pinto, Antonio [8 ]
Crispo, Anna [2 ]
Grimaldi, Maria [2 ]
Franceschi, Silvia [9 ]
Dal Maso, Luigino [1 ]
Serraino, Diego [1 ]
机构
[1] CRO Aviano Natl Canc Inst, Canc Epidemiol Unit, Via Franco Gallini 2, I-33081 Aviano, Italy
[2] G Pascale Fdn, Natl Canc Inst, Epidemiol Unit, I-80131 Naples, Italy
[3] Univ Catania, Dept Biomed Sci, Via Androne 83, I-95124 Catania, Italy
[4] CRO Aviano Natl Canc Inst, Unit Microbiol Immunol & Virol, Via Franco Gallini 2, I-33081 Aviano, Italy
[5] CRO Aviano Natl Canc Inst, Unit Stem Cells Collect & Proc Unit Cells Therapy, Via Franco Gallini 2, I-33081 Aviano, Italy
[6] CRO Aviano Natl Canc Inst, Unit Med Oncol A, Via Franco Gallini 2, I-33081 Aviano, Italy
[7] Univ Catania, Azienda Policlin OVE, Div Hematol, Via Citelli 6, I-95124 Catania, Italy
[8] G Pascale Fdn, Natl Canc Inst, UOSC Ematol Oncol, Via M Semmola, I-80131 Naples, Italy
[9] Int Agcy Res Canc, 150 Cours Albert Thomas, F-69008 Lyon, France
来源
INFECTIOUS AGENTS AND CANCER | 2016年 / 11卷
关键词
Non-Hodgkin lymphoma; Hepatitis C virus; Hepatitis B virus; Case-control study; INFECTION; MALIGNANCIES; METAANALYSIS; PREVALENCE; AREA;
D O I
10.1186/s13027-016-0073-x
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Hepatitis C virus (HCV) has been consistently associated to non-Hodgkin lymphoma (NHL); conversely, few studies have evaluated a comprehensive serological panel of hepatitis B virus (HBV) in NHL etiology. Methods: We conducted a case-control study in Italy in 1999-2014, enrolling 571 incident, histologically confirmed NHLs and 1004 cancer-free matched controls. Study subjects provided serum for HCV and HBV testing and for HCV RNA. Odds ratios (ORs) and corresponding 95 % confidence intervals (CIs) were estimated by logistic regression, adjusting for potential confounders. Results: Circulating HCV RNA was detected in 63 (11.1 %) NHL cases and 35 (3.5 %) controls (OR = 3.51, 95 % CI: 2.25-5.47). Chronic HBV infection (i.e., positive to HBV surface antigen - HBsAg(+)) was found in 3.7 % of cases and 1.7 % of controls (OR = 1.95, 95 % CI: 1.00-3.81); a significantly elevated OR was observed for B-cell NHL (2.11, 95 % CI: 1.07-4.15). People with serological evidence of past HCV or HBV infection, vaccination against HBV, or detectable antibodies against HBV core antigen (anti-HBc(+)) alone were not at increased NHL risk. Conclusions: Our results support a role of chronic HCV infection in NHL in Italy and suggest an involvement of HBV infection. Associations were clearest for B-cell NHL and diffuse large B-cell lymphoma. Prevention and treatment of HCV and HBV infection may diminish NHL incidence, notably in areas with high prevalence of hepatitis viruses infection.
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页数:6
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