Hepatitis B and C viruses and risk of non-Hodgkin lymphoma: a case-control study in Italy

被引:40
|
作者
Taborelli, Martina [1 ]
Polesel, Jerry [1 ]
Montella, Maurizio [2 ]
Libra, Massimo [3 ]
Tedeschi, Rosamaria [4 ]
Battiston, Monica [5 ]
Spina, Michele [6 ]
Di Raimondo, Francesco [7 ]
Pinto, Antonio [8 ]
Crispo, Anna [2 ]
Grimaldi, Maria [2 ]
Franceschi, Silvia [9 ]
Dal Maso, Luigino [1 ]
Serraino, Diego [1 ]
机构
[1] CRO Aviano Natl Canc Inst, Canc Epidemiol Unit, Via Franco Gallini 2, I-33081 Aviano, Italy
[2] G Pascale Fdn, Natl Canc Inst, Epidemiol Unit, I-80131 Naples, Italy
[3] Univ Catania, Dept Biomed Sci, Via Androne 83, I-95124 Catania, Italy
[4] CRO Aviano Natl Canc Inst, Unit Microbiol Immunol & Virol, Via Franco Gallini 2, I-33081 Aviano, Italy
[5] CRO Aviano Natl Canc Inst, Unit Stem Cells Collect & Proc Unit Cells Therapy, Via Franco Gallini 2, I-33081 Aviano, Italy
[6] CRO Aviano Natl Canc Inst, Unit Med Oncol A, Via Franco Gallini 2, I-33081 Aviano, Italy
[7] Univ Catania, Azienda Policlin OVE, Div Hematol, Via Citelli 6, I-95124 Catania, Italy
[8] G Pascale Fdn, Natl Canc Inst, UOSC Ematol Oncol, Via M Semmola, I-80131 Naples, Italy
[9] Int Agcy Res Canc, 150 Cours Albert Thomas, F-69008 Lyon, France
来源
INFECTIOUS AGENTS AND CANCER | 2016年 / 11卷
关键词
Non-Hodgkin lymphoma; Hepatitis C virus; Hepatitis B virus; Case-control study; INFECTION; MALIGNANCIES; METAANALYSIS; PREVALENCE; AREA;
D O I
10.1186/s13027-016-0073-x
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Hepatitis C virus (HCV) has been consistently associated to non-Hodgkin lymphoma (NHL); conversely, few studies have evaluated a comprehensive serological panel of hepatitis B virus (HBV) in NHL etiology. Methods: We conducted a case-control study in Italy in 1999-2014, enrolling 571 incident, histologically confirmed NHLs and 1004 cancer-free matched controls. Study subjects provided serum for HCV and HBV testing and for HCV RNA. Odds ratios (ORs) and corresponding 95 % confidence intervals (CIs) were estimated by logistic regression, adjusting for potential confounders. Results: Circulating HCV RNA was detected in 63 (11.1 %) NHL cases and 35 (3.5 %) controls (OR = 3.51, 95 % CI: 2.25-5.47). Chronic HBV infection (i.e., positive to HBV surface antigen - HBsAg(+)) was found in 3.7 % of cases and 1.7 % of controls (OR = 1.95, 95 % CI: 1.00-3.81); a significantly elevated OR was observed for B-cell NHL (2.11, 95 % CI: 1.07-4.15). People with serological evidence of past HCV or HBV infection, vaccination against HBV, or detectable antibodies against HBV core antigen (anti-HBc(+)) alone were not at increased NHL risk. Conclusions: Our results support a role of chronic HCV infection in NHL in Italy and suggest an involvement of HBV infection. Associations were clearest for B-cell NHL and diffuse large B-cell lymphoma. Prevention and treatment of HCV and HBV infection may diminish NHL incidence, notably in areas with high prevalence of hepatitis viruses infection.
引用
收藏
页数:6
相关论文
共 50 条
  • [1] Hepatitis B and C viruses and risk of non-Hodgkin lymphoma: a case-control study in Italy
    Martina Taborelli
    Jerry Polesel
    Maurizio Montella
    Massimo Libra
    Rosamaria Tedeschi
    Monica Battiston
    Michele Spina
    Francesco Di Raimondo
    Antonio Pinto
    Anna Crispo
    Maria Grimaldi
    Silvia Franceschi
    Luigino Dal Maso
    Diego Serraino
    Infectious Agents and Cancer, 11
  • [2] Smoking and non-Hodgkin lymphoma: Case-control study in Italy
    Talamini, R
    Polesel, J
    Montella, M
    dal Maso, L
    Crispo, A
    Spina, M
    Franceschi, S
    Crovatto, M
    La Vecchia, C
    INTERNATIONAL JOURNAL OF CANCER, 2005, 115 (04) : 606 - 610
  • [3] Food groups and risk of non-Hodgkin lymphoma: A multicenter, case-control study in Italy
    Talamini, R
    Polesel, J
    Montella, M
    Dal Maso, L
    Crovatto, M
    Crispo, A
    Spina, M
    Canzonieri, V
    La Vecchia, C
    Franceschi, S
    INTERNATIONAL JOURNAL OF CANCER, 2006, 118 (11) : 2871 - 2876
  • [4] Non-Hodgkin's lymphoma and hepatitis C virus: A case-control study from northern and southern Italy
    Talamini, R
    Montella, M
    Crovatto, M
    Dal Maso, L
    Crispo, A
    Negri, E
    Spina, M
    Pinto, A
    Carbone, A
    Franceschi, S
    INTERNATIONAL JOURNAL OF CANCER, 2004, 110 (03) : 380 - 385
  • [5] Diabetes and risk of non-Hodgkin lymphoma: A case-control study
    Scotti, Lorenza
    Tavani, Alessandra
    Bosetti, Cristina
    Dal Maso, Luigino
    Talamini, Renato
    Montella, Maurizio
    Franceschi, Silvia
    La Vecchia, Carlo
    TUMORI, 2007, 93 (01) : 1 - 3
  • [6] Hepatitis C Virus Infection in Non-Hodgkin's Lymphoma: A Case-Control Study
    Muhammad, Shaikh Khalid
    Chandio, Mujahid Ali
    Soomro, Muhammad Aslam
    Shaikh, Bashir Ahmaed
    HEPATITIS MONTHLY, 2012, 12 (01) : 16 - 22
  • [7] Case-control study of non-Hodgkin's lymphoma and hepatitis C virus infection in Egypt
    Cowgill, KD
    Loffredo, CA
    Eissa, SAL
    Mokhtar, N
    Abdel-Hamid, M
    Fahmy, A
    Strickland, GT
    INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2004, 33 (05) : 1034 - 1039
  • [8] Non-Hodgkin lymphoma in Uganda: a case-control study
    Parkin, DM
    Garcia-Giannoli, H
    Raphael, M
    Martin, A
    Katangole-Mbidde, E
    Wabinga, H
    Ziegler, J
    AIDS, 2000, 14 (18) : 2929 - 2936
  • [9] Polychlorinated biphenyls and non-Hodgkin's lymphoma: A case-control study in Northern Italy
    Maifredi, Giovanni
    Donato, Francesco
    Magoni, Michele
    Orizio, Grazia
    Gelatti, Umberto
    Maiolino, Pierpaolo
    Zani, Claudia
    Vassallo, Francesco
    Scarcella, Carmelo
    ENVIRONMENTAL RESEARCH, 2011, 111 (02) : 254 - 259
  • [10] Hepatitis B Virus Infection and Risk of Non-Hodgkin Lymphoma: A Meta-Analysis of Case-Control Studies
    Kanth, Rajan
    Inaganti, Anupama
    Samji, Naga Swetha
    Komanapalli, Sarah D.
    Borg, Brian B.
    Roy, Praveen K.
    GASTROENTEROLOGY, 2013, 144 (05) : S974 - S974