In vitro and in vivo cytotoxicities and antileishmanial activities of thymol and hemisynthetic derivatives

被引：78

作者：

Robledo, S

Osorio, E

Muñoz, D

Jaramillo, LM

Restrepo, A

Arango, G

Vélez, I

机构：

[1] Univ Antioquia, PECET, Medellin, Colombia

[2] Univ Antioquia, Grp Invest Sustancias Bioactivas, GISB, Medellin, Colombia

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 04期

关键词：

D O I：

10.1128/AAC.49.4.1652-1655.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The in vitro and in vivo antileishmanial and cytotoxic activities of thymol and structural derivatives in comparison to those of Glucantime were studied. The results showed here suggest that thymol and hemisynthetic derivatives have promising antileishmanial potential and could be considered as new lead structures in the search for novel antileishmanial drugs.

引用

页码：1652 / 1655

页数：4

共 50 条

[41] Design, Synthesis, and In Vitro Antileishmanial and Antitumor Activities of New Tetrahydroquinolines
Madkour, Hassan Mohamed Fawzy
El-Hashash, Maher Abd El-Aziz Mahmoud
Salem, Marwa Sayed
Mahmoud, Al-Shimaa Omar Ali
Al Kahraman, Yasser M. S. A.
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2018, 55 (02) : 391 - 401
[42] In vitro antileishmanial and immunomodulatory activities of the synthetic analogue riparin E
Costa, Luciana Muratori
de Moraes Alves, Michel Mualem
Brito, Lucas Moreira
Abi-chacra, Erika de Araujo
Barbosa-Filho, Jose Maria
Chavez Gutierrez, Stanley Juan
Barreto, Humberto Medeiros
de Amorim Carvalho, Fernando Aecio
CHEMICO-BIOLOGICAL INTERACTIONS, 2021, 336
[43] Synthesis, antileishmanial and cytotoxicity activities of fused and nonfused tetrahydroquinoline derivatives
Madkour, Hassan Mohamed Fawzy
El-Hashash, Maher Abd El-Aziz Mahmoud
Salem, Marwa Sayed
Mahmoud, Al-Shimaa Omar Ali
RESEARCH ON CHEMICAL INTERMEDIATES, 2018, 44 (05) : 3349 - 3364
[44] In vitro and in vivo antileishmanial activity of 2-amino-4,6-dimethylpyridine derivatives against Leishmania mexicana
Abdala, H
Alvarez, N
Delmas, F
Di Giorgio, C
Robert, JM
Le Baut, G
Le Pape, P
PARASITE, 2002, 9 (04) : 367 - 370
[45] In vitro and in vivo pharmacodynamics of three novel antileishmanial lead series
Van den Kerkhof, M.
Mabille, D.
Chatelain, E.
Mowbray, C. E.
Braillard, S.
Hendrickx, S.
Maes, L.
Caljon, G.
INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE, 2018, 8 (01): : 81 - 86
[46] In vitro and in vivo antileishmanial efficacy of nitazoxanide against Leishmania donovani
Ruiyan Zhang
Liming Shang
Hongtao Jin
Cuiping Ma
Yongkui Wu
Quan Liu
Zhiping Xia
Feng Wei
Xing-Quan Zhu
Hongwei Gao
Parasitology Research, 2010, 107 : 475 - 479
[47] In Vivo Antimalarial and In Vitro Antileishmanial Activity of 4-Aminoquinoline Derivatives Hybridized to Isoniazid or Sulfa or Hydrazine Groups
Soares, Roberta R.
Antinarelli, Luciana M. R.
Souza, Isabela de O.
Lopes, Fernanda V.
Scopel, Kezia K. G.
Coimbra, Elaine S.
da Silva, Adilson D.
Abramo, Clarice
LETTERS IN DRUG DESIGN & DISCOVERY, 2017, 14 (05) : 597 - 604
[48] SYNTHESIS, LARVICIDAL AND ACETYLCHOLINESTERASE INHIBITORY ACTIVITIES OF CARVACROL/THYMOL AND DERIVATIVES
de Mesquita, Bruna M.
do Nascimento, Patricia G. G.
Souza, Luciana G. S.
de Farias, Iolanda F.
da Silva, Romezio A. C.
de Lemos, Telma L. G.
Monte, Francisco J. Q.
Oliveira, Irvila R.
Trevisan, Maria T. S.
da Silva, Horlando C.
Santiago, Gilvandete M. P.
QUIMICA NOVA, 2018, 41 (04): : 412 - 416
[49] Thymol derivatives from the roots of Eupatorium chinense and their cytotoxic activities
Zhang, Qing-Qing
Sun, Zhi-Ying
Feng, Xue-Yun
Chen, Run-Jie
Deng, Wen
Tang, Yong-Li
Guo, Zhi-Yong
Liu, Cheng-Xiong
Chen, Jian-Feng
Zou, Kun
PHYTOCHEMISTRY LETTERS, 2019, 29 : 165 - 168
[50] Designing Antitrypanosomal and Antileishmanial BODIPY Derivatives: A Computational and In Vitro Assessment
Goncalves, Raquel C. R.
Teixeira, Filipe
Penalver, Pablo
Costa, Susana P. G.
Morales, Juan C.
Raposo, M. Manuela M.
MOLECULES, 2024, 29 (09):

← 1 2 3 4 5 →