Safety and efficacy of low-dose esterified estrogens and methyltestosterone, alone or combined, for the treatment of hot flashes in menopausal women: a randomized, double-blind, placebo-controlled study

被引：6

作者：

Liu, James ^{[1
]}

Allgood, Adam ^{[2
]}

Derogatis, Leonard R. ^{[3
]}

Swanson, Stephen ^{[4
]}

O'Mahony, Michael ^{[5
]}

Nedoss, Bertrand ^{[6
]}

Soper, Herbert ^{[7
]}

Zbella, Edward ^{[8
]}

Prokofieva, Svetlana Vladimirovna ^{[9
]}

Zipfel, Lisa ^{[2
]}

Guo, Chun-Yuan ^{[2
]}

机构：

[1] Case Western Reserve Univ, Sch Med, MacDonald Womens Hosp, Case Med Ctr, Cleveland, OH USA

[2] Abbott, Marietta, GA USA

[3] Ctr Sexual Med Sheppard Pratt, Baltimore, MD USA

[4] Womens Clin Lincoln PC, Lincoln, NE USA

[5] London Rd Diagnost Clin, Sarnia, ON, Canada

[6] Radiant Res, Tucson, AZ USA

[7] Piedmont Med Res, Winston Salem, NC USA

[8] Womens Med Res Grp LLC, Clearwater, FL USA

[9] Fed Med Biol Agcy Russia, Moscow, Russia

来源：

FERTILITY AND STERILITY | 2011年 / 95卷 / 01期

关键词：

Postmenopausal women; vasomotor symptoms; hot flashes; hormone replacement therapy; esterified estrogens (EE); methyltestosterone (MT); lowest effective dose; POSTMENOPAUSAL WOMEN; CONTROLLED-TRIAL; HUMAN AROMATASE; BREAST-CANCER; ANDROGEN; THERAPY; HEALTH; ENDOCRINE; PROFILES; SYMPTOMS;

D O I：

10.1016/j.fertnstert.2010.08.005

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

This study evaluated safety and efficacy of esterified estrogens and methyltestosterone administered alone or in combination for the treatment of hot flashes in menopausal women. The 0.30-mg esterified estrogens and 0.30-mg methyltestosterone combination was the lowest effective dose, and our results are consistent with the known safety profile of estrogen and androgen combination products. (Fertil Steril (R) 2011; 95:366-8. (c) 2011 by American Society for Reproductive Medicine.)

引用

页码：366 / 368

页数：3

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