The effectiveness of interferon therapy on occurrence of hepatocellular carcinoma in chronic hepatitis C

被引：0

作者：

Horiike, N ^{[1
]}

Fujisawa, T ^{[1
]}

Michitaka, K ^{[1
]}

Tada, K ^{[1
]}

Masumoto, T ^{[1
]}

Iuchi, H ^{[1
]}

Kojima, N ^{[1
]}

Onji, M ^{[1
]}

机构：

[1] Ehime Univ, Sch Med, Dept Internal Med 3, Matsuyama, Ehime 7910295, Japan

来源：

ONCOLOGY REPORTS | 1998年 / 5卷 / 05期

关键词：

chronic hepatitis C; hepatocellular carcinoma; interferon;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To clarify the effect of interferon (IFN) therapy for chronic hepatitis C (CHC) on the occurrence of hepatocellular carcinoma (HCC), 149 patients who were observed over a period of five years (mean: 7.6 years) were studied. The C-1 group, 33 patients with complete response to IFN; the C-2 group, 55 patients with no response to IFN; and the C-3 group, 61 patients who did not receive IFN. The occurrence rate of HCC was 0.9%/year/person. In the C-1, C-2 and C-3 groups, the rates were 0%, 0.3%, and 1.6%, respectively. The rate in C-1 + C-2 groups was significantly lower than that of the C-3 group (P<0.05). These data suggest IFN may suppress the occurrence of HCC in CHC.

引用

页码：1171 / 1174

页数：4

共 17 条

[1] Hepatitis C virus genotypes and risk of hepatocellular carcinoma in cirrhosis: A prospective study [J].

Bruno, S ;

Silini, E ;

Crosignani, A ;

Borzio, F ;

Leandro, G ;

Bono, F ;

Asti, M ;

Rossi, S ;

Larghi, A ;

Cerino, A ;

Podda, M ;

Mondelli, MU .

HEPATOLOGY, 1997, 25 (03) :754-758

[2] TREATMENT OF CHRONIC HEPATITIS-C WITH RECOMBINANT INTERFERON-ALFA - A MULTICENTER RANDOMIZED, CONTROLLED TRIAL [J].

DAVIS, GL ;

BALART, LA ;

SCHIFF, ER ;

LINDSAY, K ;

BODENHEIMER, HC ;

PERRILLO, RP ;

CAREY, W ;

JACOBSON, IM ;

PAYNE, J ;

DIENSTAG, JL ;

VANTHIEL, DH ;

TAMBURRO, C ;

LEFKOWITCH, J ;

ALBRECHT, J ;

MESCHIEVITZ, C ;

ORTEGO, TJ ;

GIBAS, A .

NEW ENGLAND JOURNAL OF MEDICINE, 1989, 321 (22) :1501-1506

[3]

DESMET VJ, 1994, HEPATOLOGY, V19, P1513, DOI 10.1002/hep.1840190629

[4] Association between chronic hepatitis C infection and hepatocellular carcinoma in a Scottish population [J].

Haydon, GH ;

Jarvis, LM ;

Simmonds, P ;

Harrison, DJ ;

Garden, OJ ;

Hayes, PC .

GUT, 1997, 40 (01) :128-132

[5] HEPATITIS-C VIRUS PLUS-STRAND AND MINUS-STRAND RNA IN HEPATOCELLULAR-CARCINOMA AND ADJOINING NONTUMOROUS LIVER [J].

HORIIKE, N ;

NONAKA, T ;

KUMAMOTO, I ;

KAJINO, K ;

ONJI, M ;

OHTA, Y .

JOURNAL OF MEDICAL VIROLOGY, 1993, 41 (04) :312-315

[6] Response to interferon in chronic hepatitis C due to mixed genotype infection [J].

Horiike, N ;

Masumoto, T ;

Michitaka, K ;

Kurose, K ;

Akbar, SMF ;

Onji, M .

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 1996, 11 (04) :353-357

[7] HCV GENOTYPES IN CHRONIC HEPATITIS-C AND RESPONSE TO INTERFERON [J].

KANAI, K ;

KAKO, M ;

OKAMOTO, H .

LANCET, 1992, 339 (8808) :1543-1543

[8] INTERRELATIONSHIP OF BLOOD-TRANSFUSION, NON-A, NON-B HEPATITIS AND HEPATOCELLULAR-CARCINOMA - ANALYSIS BY DETECTION OF ANTIBODY TO HEPATITIS-C VIRUS [J].

KIYOSAWA, K ;

SODEYAMA, T ;

TANAKA, E ;

GIBO, Y ;

YOSHIZAWA, K ;

NAKANO, Y ;

FURUTA, S ;

AKAHANE, Y ;

NISHIOKA, K ;

PURCELL, RH ;

ALTER, HJ .

HEPATOLOGY, 1990, 12 (04) :671-675

[9] Alpha interferon treatment may prevent hepatocellular carcinoma in HCV-related liver cirrhosis [J].

Mazzella, G ;

Accogli, E ;

Sottili, S ;

Festi, D ;

Orsini, M ;

Salzetta, A ;

Novelli, V ;

Cipolla, A ;

Fabbri, C ;

Pezzoli, A ;

Roda, E .

JOURNAL OF HEPATOLOGY, 1996, 24 (02) :141-147

[10] RANDOMIZED TRIAL OF EFFECTS OF INTERFERON-ALPHA ON INCIDENCE OF HEPATOCELLULAR-CARCINOMA IN CHRONIC ACTIVE HEPATITIS-C WITH CIRRHOSIS [J].

NISHIGUCHI, S ;

KUROKI, T ;

NAKATANI, S ;

MORIMOTO, H ;

TAKEDA, T ;

NAKAJIMA, S ;

SHIOMI, S ;

SEKI, S ;

KOBAYASHI, K ;

OTANI, S .

LANCET, 1995, 346 (8982) :1051-1055

← 1 2 →