3-Alkenyl-oxindoles: Natural Products, Pharmaceuticals, and Recent Synthetic Advances in Tandem/Telescoped Approaches

被引：341

作者：

Millemaggi, Alessia ^{[1
]}

Taylor, Richard J. K. ^{[1
]}

机构：

[1] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 2010卷 / 24期

基金：

英国工程与自然科学研究理事会;

关键词：

Nitrogen heterocycles; Natural products; Antitumor agents; Domino reactions; Telescoped reactions; PALLADIUM-CATALYZED CYCLIZATION; C-H FUNCTIONALIZATION; PROTEASOME INHIBITORS TMC-95A; DEPENDENT KINASE INHIBITORS; STEREOSELECTIVE-SYNTHESIS; SELECTIVE SYNTHESIS; OXINDOLE ALKALOIDS; CELL-CYCLE; 2-(ALKYNYL)ARYL ISOCYANATES; 2-OXINDOLE DERIVATIVES;

D O I：

10.1002/ejoc.201000643

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The structures and biological activities of naturally occurring 3-alkenyl-oxindoles are reviewed. Important man-made 3-alkenyl-oxindoles are covered, particularly those with pharmaceutical applications such as sunitinib (SU11248), the orally active receptor tyrosine kinase inhibitor marketed by Pfizer as Sutent (R). Traditional synthetic approaches to 3-alkenyl-oxindoles are summarised and then recently developed tandem/telescoped synthetic routes are described.

引用

页码：4527 / 4547

页数：21

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