Grey matter volume in developmental speech and language disorder

被引:15
作者
Pigdon, Lauren [1 ,2 ]
Willmott, Catherine [2 ,8 ]
Reilly, Sheena [1 ,7 ]
Conti-Ramsden, Gina [1 ,6 ]
Gaser, Christian [9 ]
Connelly, Alan [3 ,4 ]
Morgan, Angela T. [1 ,4 ,5 ]
机构
[1] Murdoch Childrens Res Inst, 50 Flemington Rd, Parkville, Vic 3052, Australia
[2] Monash Univ, Turner Inst Brain & Mental Hlth, 18 Innovat Walk, Clayton, Vic 3800, Australia
[3] Florey Inst Neurosci & Mental Hlth, 245 Burgundy St, Heidelberg, Vic 3084, Australia
[4] Univ Melbourne, Grattan St, Parkville, Vic 3010, Australia
[5] Royal Childrens Hosp, 50 Flemington Rd, Parkville, Vic 3052, Australia
[6] Univ Manchester, Oxford Rd, Manchester M13 9PL, Lancs, England
[7] Griffith Univ, Menzies Hlth Inst Queensland, G40 Level 8-86, Mt Gravatt, Qld 4222, Australia
[8] Monash Univ, Monash Epworth Rehabil Res Ctr, 18 Innovat Walk, Clayton, Vic 3800, Australia
[9] Jena Univ Hosp, Klinikum 1, D-07747 Jena, Germany
基金
英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;
关键词
Language; Speech; Child; VBM; MRI; SCHOOL-AGE-CHILDREN; WHITE-MATTER; SOUND DISORDER; FOLLOW-UP; BRAIN; CEREBELLUM; PERCEPTION; LITERACY; DELAY; ABNORMALITIES;
D O I
10.1007/s00429-019-01978-7
中图分类号
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号
100101 ;
摘要
Developmental language disorder (DLD) and developmental speech disorder (DSD) are common, yet their etiologies are not well understood. Atypical volume of the inferior and posterior language regions and striatum have been reported in DLD; however, variability in both methodology and study findings limits interpretations. Imaging research within DSD, on the other hand, is scarce. The present study compared grey matter volume in children with DLD, DSD, and typically developing speech and language. Compared to typically developing controls, children with DLD had larger volume in the right cerebellum, possibly associated with the procedural learning deficits that have been proposed in DLD. Children with DSD showed larger volume in the left inferior occipital lobe compared to controls, which may indicate a compensatory role of the visual processing regions due to sub-optimal auditory-perceptual processes. Overall, these findings suggest that different neural systems may be involved in the specific deficits related to DLD and DSD.
引用
收藏
页码:3387 / 3398
页数:12
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