Developing Vaccines to Combat Pandemic Influenza

被引：18

作者：

Robertson, James S. ^{[1
]}

Engelhardt, Othmar G. ^{[1
]}

机构：

[1] Natl Inst Biol Stand & Controls, Div Virol, Hlth Protect Agcy, Potters Bar EN6 3QG, Herts, England

来源：

VIRUSES-BASEL | 2010年 / 2卷 / 02期

基金：

英国医学研究理事会;

关键词：

pandemic influenza vaccines; reverse genetics; H5N1; virus; H1N1v virus; REVERSE GENETICS SYSTEM; A VIRUS GENERATION; AVIAN INFLUENZA; H5N1; INFLUENZA; HEMAGGLUTININ CLEAVAGE; RANDOMIZED-TRIAL; STRAINS; GENOME; GROWTH; SAFETY;

D O I：

10.3390/v2020532

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Influenza vaccine manufacturers require antigenically relevant vaccine viruses that have good manufacturing properties and are safe to use. In developing pandemic vaccine viruses, reverse genetics has been employed as a rational approach that can also be used effectively to attenuate the highly virulent H5N1 virus and at the same time place the H5 HA and N1 NA on a background of PR8, a virus that has been used over many decades to provide high yielding vaccine viruses. Reverse genetics has also been used successfully alongside classical reassorting techniques in the development of (swine flu) pandemic A(H1N1) v vaccine viruses.

引用

收藏

页码：532 / 546

页数：15

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