The reference intervals for renal function indexes in chinese pregnant women

The purpose of the present research was to establish reference intervals for renal function indexes (Cystatin C, Blood Urea Nitrogen Creatinine and Uric Acid) in pregnant women in China. Blood samples were collected from 203 healthy non-pregnant women and 623 healthy pregnant women in different trimesters. Samples from 23 healthy consecutive pregnant women were collected to validate. Serum Cystatin C was measured by latex particle enhanced immune turbidity assay (Dade Behring, Germany) using Centaur 2400 (Siemens, New York, USA). Creatinine, Blood Urea Nitrogen and Uric Acid were measured by conventional enzymatic assay using a Centaur 2400 (Siemens, New York, USA). The calculated reference intervals for serum cystatin C were (0.76 +/- 0.12) mg/L, (0.70 +/- 0.14) mg/L, (0.75 +/- 0.16) mg/L, (1.19 +/- 0.23) mg/L in control group, 1st trimester, 2nd trimester and 31d trimester, respectively. Creatinine were (54.21 +/- 7.49) mu mol/L, (45.90 +/- 8.55) mu mol/L, (44.56 +/- 8.65) mu mol/L, (52.78 +/- 11.76) mu mol/L in each group. Blood Urea Nitrogen were (4.74 +/- 1.24) mu mol/L, (3.52 +/- 1.44) mu mol/L, (3.81 +/- 2.32) mu mol/L, (3.95 +/- 1.54) mu mol/L. And Uric Acid were (281.35 +/- 63.61) mu mol/L, (226.93 +/- 25.20) mu mol/L, (252.39 +/- 62.32) mu mol/L, (350.86 +/- 93.31) mu mol/L. In addition, all the data of consecutive pr egnant women were in the central 95% intervals. The results show the necessity to establish the special reference intervals for pregnancy, even each trimester. Different areas show the different intervals, indicating we need own ones in our region, and we provided. And Cystatin C is the most stable between these indexes. But we also should cautiously treat it in the 3st trimester.