P2X7 Receptor-Associated Programmed Cell Death in the Pathophysiology of Hemorrhagic Stroke

被引:54
作者
Zhao, Hengli [1 ]
Chen, Yujie [1 ]
Feng, Hua [1 ]
机构
[1] Third Mil Med Univ, Southwest Hosp, Dept Neurosurg, 29 Gaotanyan St, Chongqing 400038, Peoples R China
基金
中国国家自然科学基金;
关键词
P2X7; receptor; apoptosis; autophagy; necroptosis; pyroptosis; intracerebral hemorrhage; subarachnoid hemorrhage; CENTRAL-NERVOUS-SYSTEM; EXPERIMENTAL SUBARACHNOID HEMORRHAGE; EXPERIMENTAL INTRACEREBRAL HEMORRHAGE; ACTIVATED PROTEIN-KINASE; TRAUMATIC BRAIN-INJURY; NLRP3 INFLAMMASOME ACTIVATION; P2X(7) PURINERGIC RECEPTOR; CEREBRAL-ARTERY OCCLUSION; APOPTOSIS-INDUCING FACTOR; ION-CHANNEL P2X7;
D O I
10.2174/1570159X16666180516094500
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Hemorrhagic stroke is a life-threatening disease characterized by a sudden rupture of cerebral blood vessels, and cell death is widely believed to occur after exposure to blood metabolites or subsequently damaged cells. Recently, programmed cell death, such as apoptosis, autophagy, necroptosis, pyroptosis, and ferroptosis, has been demonstrated to play crucial roles in the pathophysiology of stroke. However, the detailed mechanisms of these novel kinds of cell death are still unclear. The P2X7 receptor, previously known for its cytotoxic activity, is an ATP-gated, nonselective cation channel that belongs to the family of ionotropic P2X receptors. Evolving evidence indicates that the P2X7 receptor plays a pivotal role in central nervous system pathology; genetic deletion and pharmacological blockade of the P2X7 receptor provide neuroprotection in various neurological disorders, including intracerebral hemorrhage and subarachnoid hemorrhage. The P2X7 receptor may regulate programmed cell death via (I) exocytosis of secretory lysosomes, (II) exocytosis of autophagosomes or autophagolysosomes during formation of the initial autophagic isolation membrane or omegasome, and (III) direct release of cytosolic IL-1 beta secondary to regulated cell death by pyroptosis or necroptosis. In this review, we present an overview of P2X7 receptor-associated programmed cell death for further understanding of hemorrhagic stroke pathophysiology, as well as potential therapeutic targets for its treatment.
引用
收藏
页码:1282 / 1295
页数:14
相关论文
共 188 条
[1]   Caspase-11 Protects Against Bacteria That Escape the Vacuole [J].
Aachoui, Youssef ;
Leaf, Irina A. ;
Hagar, Jon A. ;
Fontana, Mary F. ;
Campos, Cristine G. ;
Zak, Daniel E. ;
Tan, Michael H. ;
Cotter, Peggy A. ;
Vance, Russell E. ;
Aderem, Alan ;
Miao, Edward A. .
SCIENCE, 2013, 339 (6122) :975-978
[2]   Pyroptotic neuronal cell death mediated by the AIM2 inflammasome [J].
Adamczak, Stephanie E. ;
Vaccari, Juan Pablo de Rivero ;
Dale, Gordon ;
Brand, Frank J., III ;
Nonner, Doris ;
Bullock, M. Ross ;
Dahl, Gerhard P. ;
Dietrich, W. Dalton ;
Keane, Robert W. .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2014, 34 (04) :621-629
[3]   FasL-triggered death of Jurkat cells requires caspase 8-induced, ATP-dependent cross-talk between Fas and the purinergic receptor P2X7 [J].
Aguirre, Adam ;
Shoji, Kenji F. ;
Saez, Juan C. ;
Henriquez, Mauricio ;
Quest, Andrew F. G. .
JOURNAL OF CELLULAR PHYSIOLOGY, 2013, 228 (02) :485-493
[4]   Is pannexin the pore associated with the P2X7 receptor? [J].
Alberto, A. V. P. ;
Faria, R. X. ;
Couto, C. G. C. ;
Ferreira, L. G. B. ;
Souza, C. A. M. ;
Teixeira, P. C. N. ;
Froes, M. M. ;
Alves, L. A. .
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2013, 386 (09) :775-787
[5]   Pharmacokinetic and pharmacodynamic profiling of a P2X7 receptor allosteric modulator GSK1482160 in healthy human subjects [J].
Ali, Zahid ;
Laurijssens, Bart ;
Ostenfeld, Thor ;
McHugh, Simon ;
Stylianou, Anastasia ;
Scott-Stevens, Paul ;
Hosking, Louise ;
Dewit, Odile ;
Richardson, Jill C. ;
Chen, Chao .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2013, 75 (01) :197-207
[6]   Physiological Roles and Potential Therapeutic Applications of the P2X7 Receptor in Inflammation and Pain [J].
Alves, Luiz Anastacio ;
Soares Bezerra, Romulo Jose ;
Faria, Robson Xavier ;
Braga Ferreira, Leonardo Gomes ;
Frutuoso, Valber da Silva .
MOLECULES, 2013, 18 (09) :10953-10972
[7]   P2X7 receptor antagonism reduces the severity of spontaneous seizures in a chronic model of temporal lobe epilepsy [J].
Amhaoul, Halima ;
Ali, Idrish ;
Mola, Marco ;
Van Eetveldt, Annemie ;
Szewczyk, Krystyna ;
Missault, Stephan ;
Bielen, Kenny ;
Kumar-Singh, Samir ;
Rech, Jason ;
Lord, Brian ;
Ceusters, Marc ;
Bhattacharya, Anindya ;
Dedeurwaerdere, Stefanie .
NEUROPHARMACOLOGY, 2016, 105 :175-185
[8]   Emerging challenges of assigning P2X7 receptor function and immunoreactivity in neurons [J].
Anderson, CM ;
Nedergaard, M .
TRENDS IN NEUROSCIENCES, 2006, 29 (05) :257-262
[9]   P2X7 receptor blockade prevents ATP excitotoxicity in neurons and reduces brain damage after ischemia [J].
Arbeloa, Joana ;
Perez-Samartin, Alberto ;
Gottlieb, Miroslav ;
Matute, Carlos .
NEUROBIOLOGY OF DISEASE, 2012, 45 (03) :954-961
[10]   Intravascular Inflammation Triggers Intracerebral Activated Microglia and Contributes to Secondary Brain Injury After Experimental Subarachnoid Hemorrhage (eSAH) [J].
Atangana, Etienne ;
Schneider, Ulf C. ;
Blecharz, Kinga ;
Magrini, Salima ;
Wagner, Josephin ;
Nieminen-Kelha, Melina ;
Kremenetskaia, Irina ;
Heppner, Frank L. ;
Engelhardt, Britta ;
Vajkoczy, Peter .
TRANSLATIONAL STROKE RESEARCH, 2017, 8 (02) :144-156