共 188 条
P2X7 Receptor-Associated Programmed Cell Death in the Pathophysiology of Hemorrhagic Stroke
被引:54
作者:

Zhao, Hengli
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机构:
Third Mil Med Univ, Southwest Hosp, Dept Neurosurg, 29 Gaotanyan St, Chongqing 400038, Peoples R China Third Mil Med Univ, Southwest Hosp, Dept Neurosurg, 29 Gaotanyan St, Chongqing 400038, Peoples R China

Chen, Yujie
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h-index: 0
机构:
Third Mil Med Univ, Southwest Hosp, Dept Neurosurg, 29 Gaotanyan St, Chongqing 400038, Peoples R China Third Mil Med Univ, Southwest Hosp, Dept Neurosurg, 29 Gaotanyan St, Chongqing 400038, Peoples R China

Feng, Hua
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h-index: 0
机构:
Third Mil Med Univ, Southwest Hosp, Dept Neurosurg, 29 Gaotanyan St, Chongqing 400038, Peoples R China Third Mil Med Univ, Southwest Hosp, Dept Neurosurg, 29 Gaotanyan St, Chongqing 400038, Peoples R China
机构:
[1] Third Mil Med Univ, Southwest Hosp, Dept Neurosurg, 29 Gaotanyan St, Chongqing 400038, Peoples R China
基金:
中国国家自然科学基金;
关键词:
P2X7;
receptor;
apoptosis;
autophagy;
necroptosis;
pyroptosis;
intracerebral hemorrhage;
subarachnoid hemorrhage;
CENTRAL-NERVOUS-SYSTEM;
EXPERIMENTAL SUBARACHNOID HEMORRHAGE;
EXPERIMENTAL INTRACEREBRAL HEMORRHAGE;
ACTIVATED PROTEIN-KINASE;
TRAUMATIC BRAIN-INJURY;
NLRP3 INFLAMMASOME ACTIVATION;
P2X(7) PURINERGIC RECEPTOR;
CEREBRAL-ARTERY OCCLUSION;
APOPTOSIS-INDUCING FACTOR;
ION-CHANNEL P2X7;
D O I:
10.2174/1570159X16666180516094500
中图分类号:
Q189 [神经科学];
学科分类号:
071006 ;
摘要:
Hemorrhagic stroke is a life-threatening disease characterized by a sudden rupture of cerebral blood vessels, and cell death is widely believed to occur after exposure to blood metabolites or subsequently damaged cells. Recently, programmed cell death, such as apoptosis, autophagy, necroptosis, pyroptosis, and ferroptosis, has been demonstrated to play crucial roles in the pathophysiology of stroke. However, the detailed mechanisms of these novel kinds of cell death are still unclear. The P2X7 receptor, previously known for its cytotoxic activity, is an ATP-gated, nonselective cation channel that belongs to the family of ionotropic P2X receptors. Evolving evidence indicates that the P2X7 receptor plays a pivotal role in central nervous system pathology; genetic deletion and pharmacological blockade of the P2X7 receptor provide neuroprotection in various neurological disorders, including intracerebral hemorrhage and subarachnoid hemorrhage. The P2X7 receptor may regulate programmed cell death via (I) exocytosis of secretory lysosomes, (II) exocytosis of autophagosomes or autophagolysosomes during formation of the initial autophagic isolation membrane or omegasome, and (III) direct release of cytosolic IL-1 beta secondary to regulated cell death by pyroptosis or necroptosis. In this review, we present an overview of P2X7 receptor-associated programmed cell death for further understanding of hemorrhagic stroke pathophysiology, as well as potential therapeutic targets for its treatment.
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页码:1282 / 1295
页数:14
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Charite, Expt Neurosurg, D-10117 Berlin, Germany Charite, Expt Neurosurg, D-10117 Berlin, Germany

Magrini, Salima
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Charite, Expt Neurosurg, D-10117 Berlin, Germany Charite, Expt Neurosurg, D-10117 Berlin, Germany

Wagner, Josephin
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Charite, Expt Neurosurg, D-10117 Berlin, Germany Charite, Expt Neurosurg, D-10117 Berlin, Germany

Nieminen-Kelha, Melina
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Charite, Expt Neurosurg, D-10117 Berlin, Germany Charite, Expt Neurosurg, D-10117 Berlin, Germany

Kremenetskaia, Irina
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Charite, Expt Neurosurg, D-10117 Berlin, Germany Charite, Expt Neurosurg, D-10117 Berlin, Germany

Heppner, Frank L.
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Charite, Dept Neuropathol, D-10117 Berlin, Germany Charite, Expt Neurosurg, D-10117 Berlin, Germany

Engelhardt, Britta
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Univ Bern, Theodor Kocher Inst, CH-3012 Bern, Switzerland Charite, Expt Neurosurg, D-10117 Berlin, Germany

Vajkoczy, Peter
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Charite, Expt Neurosurg, D-10117 Berlin, Germany
Charite, Dept Neurosurg, D-12200 Berlin, Germany
Charite, Dept Neurosurg, Augustenburger Pl 1, D-13353 Berlin, Germany Charite, Expt Neurosurg, D-10117 Berlin, Germany