Putting proteins back into water

被引：59

作者：

De Los Rios, P ^{[1
]}

Caldarelli, G

机构：

[1] Univ Fribourg, Inst Phys Theor, CH-1700 Fribourg, Switzerland

[2] Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy

[3] INFM, Sez Roma 1, I-00185 Rome, Italy

来源：

PHYSICAL REVIEW E | 2000年 / 62卷 / 06期

关键词：

D O I：

10.1103/PhysRevE.62.8449

中图分类号：

O35 [流体力学]; O53 [等离子体物理学];

学科分类号：

070204 ; 080103 ; 080704 ;

摘要：

We introduce a simplified protein model where the solvent (water) degrees of freedom appear explicitly (although in an extremely simplified fashion). Using this model we are able to recover the thermodynamic phenomenology of proteins over a wide range of temperatures. In particular we describe both the warm and the cold protein denaturation within a single framework, while addressing important issues about the structure of model proteins.

引用

页码：8449 / 8452

页数：4

共 25 条

[1] THE PROTEIN FOLDING PROBLEM [J].

CHAN, HS ;

DILL, KA .

PHYSICS TODAY, 1993, 46 (02) :24-32

[2]

CREIGHTON TE, 1993, PROTEINS STRUCTURES, P157

[3] FREE VOLUME AND ENTROPY IN CONDENSED SYSTEMS .3. ENTROPY IN BINARY LIQUID MIXTURES - PARTIAL MOLAL ENTROPY IN DILUTE SOLUTIONS - STRUCTURE AND THERMODYNAMICS IN AQUEOUS ELECTROLYTES [J].

FRANK, HS ;

EVANS, MW .

JOURNAL OF CHEMICAL PHYSICS, 1945, 13 (11) :507-532

[4]

Graziano G, 1997, J BIOCHEM, V122, P395

[5] CALORIMETRIC STUDY OF THE HEAT AND COLD DENATURATION OF BETA-LACTOGLOBULIN [J].

GRIKO, YV ;

PRIVALOV, PL .

BIOCHEMISTRY, 1992, 31 (37) :8810-8815

[6] SOME FACTORS IN THE INTERPRETATION OF PROTEIN DENATURATION [J].

KAUZMANN, W .

ADVANCES IN PROTEIN CHEMISTRY, 1959, 14 :1-63

[7] A LATTICE STATISTICAL-MECHANICS MODEL OF THE CONFORMATIONAL AND SEQUENCE-SPACES OF PROTEINS [J].

LAU, KF ;

DILL, KA .

MACROMOLECULES, 1989, 22 (10) :3986-3997

[8]

LEE B, 1996, ACCOUNTS CHEM RES, V22, P5163

[9] HEAT-CAPACITY OF PROTEINS .1. PARTIAL MOLAR HEAT-CAPACITY OF INDIVIDUAL AMINO-ACID-RESIDUES IN AQUEOUS-SOLUTION - HYDRATION EFFECT [J].

MAKHATADZE, GI ;

PRIVALOV, PL .

JOURNAL OF MOLECULAR BIOLOGY, 1990, 213 (02) :375-384

[10] Energetics of protein structure [J].

Makhatadze, GI ;

Privalov, PL .

ADVANCES IN PROTEIN CHEMISTRY, VOL 47, 1995, 47 :307-425

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