Chronic inflammation: key player and biomarker-set to predict and prevent cancer development and progression based on individualized patient profiles

被引：149

作者：

Qian, Shehua ^{[1
,2
,3
]}

Golubnitschaja, Olga ^{[4
,5
,6
]}

Zhan, Xianquan ^{[1
,2
,3
,7
,8
]}

机构：

[1] Cent South Univ, Chinese Minist Hlth, Xiangya Hosp, Key Lab Canc Prote, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China

[2] Cent South Univ, Hunan Engn Lab Struct Biol & Drug Design, Xiangya Hosp, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China

[3] Cent South Univ, State Local Joint Engn Lab Anticanc Drugs, Xiangya Hosp, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China

[4] Excellence Rheinisch Friedrich Wilhelms Univ Bonn, UKB, Radiol Clin, Sigmund Freud Str 25, D-53105 Bonn, Germany

[5] Excellence Rheinisch Friedrich Wilhelms Univ Bonn, UKB, Breast Canc Res Ctr, Bonn, Germany

[6] Excellence Rheinisch Friedrich Wilhelms Univ Bonn, Ctr Integrated Oncol, Bonn, Germany

[7] Cent South Univ, Xiangya Hosp, Dept Oncol, Changsha 410008, Hunan, Peoples R China

[8] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Hunan, Peoples R China

来源：

EPMA JOURNAL | 2019年 / 10卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Chronic inflammation; Cancer; Inflammatory factors; Biomarkers; Predictive preventive personalized medicine; Patient stratification; Individualized patient profile; Risk factors; Modifiable and preventable; Genetics; Epigenetics; Multiomics; Machine learning; Big data analysis; Global statistics; Collateral pathologies; Phenotyping; OBSTRUCTIVE PULMONARY-DISEASE; HELICOBACTER-PYLORI INFECTION; CELL LUNG-CANCER; NF-KAPPA-B; HEPATITIS-C; OXIDATIVE STRESS; BREAST-CANCER; TUMOR MICROENVIRONMENT; MOLECULAR-MECHANISMS; GASTRIC INFLAMMATION;

D O I：

10.1007/s13167-019-00194-x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A strong relationship exists between tumor and inflammation, which is the hot point in cancer research. Inflammation can promote the occurrence and development of cancer by promoting blood vessel growth, cancer cell proliferation, and tumor invasiveness, negatively regulating immune response, and changing the efficacy of certain anti-tumor drugs. It has been demonstrated that there are a large number of inflammatory factors and inflammatory cells in the tumor microenvironment, and tumor-promoting immunity and anti-tumor immunity exist simultaneously in the tumor microenvironment. The typical relationship between chronic inflammation and tumor has been presented by the relationships between Helicobacter pylori, chronic gastritis, and gastric cancer; between smoking, development of chronic pneumonia, and lung cancer; and between hepatitis virus (mainly hepatitis virus B and C), development of chronic hepatitis, and liver cancer. The prevention of chronic inflammation is a factor that can prevent cancer, so it effectively inhibits or blocks the occurrence, development, and progression of the chronic inflammation process playing important roles in the prevention of cancer. Monitoring of the causes and inflammatory factors in chronic inflammation processes is a useful way to predict cancer and assess the efficiency of cancer prevention. Chronic inflammation-based biomarkers are useful tools to predict and prevent cancer.

引用

页码：365 / 381

页数：17

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