Increased mitochondrial toxicity with ribavirin in HIV/HCV coinfection

被引：221

作者：

Lafeuillade, A ^{[1
]}

Hittinger, G ^{[1
]}

Chadapaud, S ^{[1
]}

机构：

[1] Hop Chalucet, Dept Infect Dis, Toulon, France

来源：

LANCET | 2001年 / 357卷 / 9252期

关键词：

D O I：

10.1016/S0140-6736(00)03618-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In two of 15 patients coinfected with HIV and hepatitis C virus who received interferon-alpha plus ribavirin in addition to HAART, we observed multiorgan dysfunction and lactic acidaemia. As ribavirin is a nucleoside analogue, an increased risk of mitochondrial toxicity can be induced in HIV-infected patients already treated with nucleoside analogues, leading to clinical deterioration in some cases.

引用

页码：280 / 281

页数：2

共 5 条

[1] Mitochondrial toxicity induced by nucleoside-analogue reverse-transcriptase inhibitors is a key factor in the pathogenesis of antiretroviral-therapy-related lipodystrophy [J].