Zinc transporters maintain longevity by influencing insulin/IGF-1 activity in Caenorhabditis elegans

被引：6

作者：

Novakovic, Stevan ^{[1
,2
]}

Molesworth, Luke W. ^{[3
]}

Gourley, Taylin E. ^{[3
]}

Boag, Peter R. ^{[1
,2
]}

Davis, Gregory M. ^{[3
]}

机构：

[1] Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic, Australia

[2] Monash Biomed Discovery Inst, Dev & Stem Cells Program, Clayton, Vic, Australia

[3] Federat Univ, Sch Hlth & Life Sci, Churchill, Vic, Australia

来源：

FEBS LETTERS | 2020年 / 594卷 / 09期

关键词：

Caenorhabditis elegans; zinc; development; insulin signalling; transcription factor; C-ELEGANS; LIFE-SPAN; DAF-16; PROTEIN; FAMILY; ROLES; SIGNALS; SKN-1;

D O I：

10.1002/1873-3468.13725

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Adequate dietary intake of essential metals such as zinc is important for maintaining homeostasis. Abnormal zinc intake in Caenorhabditis elegans has been shown to increase or decrease normal lifespan by influencing the insulin/IGF-1 pathway. Distribution of zinc is achieved by a family of highly conserved zinc transport proteins (ZIPT in C. elegans). This study investigated the role of the zipt family of genes and showed that depletion of individual zipt genes results in a decreased lifespan. Moreover, zipt-16 and zipt-17 mutants synthetically interact with the insulin/IGF cofactors daf-16 and skn-1, and cause abnormal localisation of DAF-16. This study suggests that the zipt family of genes are required for maintaining normal lifespan through influencing the insulin/IGF-1 pathway.

引用

页码：1424 / 1432

页数：9

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