Zinc transporters maintain longevity by influencing insulin/IGF-1 activity in Caenorhabditis elegans

被引：6
作者：
Novakovic, Stevan [1 ,2 ]
Molesworth, Luke W. [3 ]
Gourley, Taylin E. [3 ]
Boag, Peter R. [1 ,2 ]
Davis, Gregory M. [3 ]
机构：
[1] Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic, Australia
[2] Monash Biomed Discovery Inst, Dev & Stem Cells Program, Clayton, Vic, Australia
[3] Federat Univ, Sch Hlth & Life Sci, Churchill, Vic, Australia
来源：
FEBS LETTERS | 2020年 / 594卷 / 09期
关键词：
Caenorhabditis elegans; zinc; development; insulin signalling; transcription factor; C-ELEGANS; LIFE-SPAN; DAF-16; PROTEIN; FAMILY; ROLES; SIGNALS; SKN-1;
D O I：
10.1002/1873-3468.13725
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Adequate dietary intake of essential metals such as zinc is important for maintaining homeostasis. Abnormal zinc intake in Caenorhabditis elegans has been shown to increase or decrease normal lifespan by influencing the insulin/IGF-1 pathway. Distribution of zinc is achieved by a family of highly conserved zinc transport proteins (ZIPT in C. elegans). This study investigated the role of the zipt family of genes and showed that depletion of individual zipt genes results in a decreased lifespan. Moreover, zipt-16 and zipt-17 mutants synthetically interact with the insulin/IGF cofactors daf-16 and skn-1, and cause abnormal localisation of DAF-16. This study suggests that the zipt family of genes are required for maintaining normal lifespan through influencing the insulin/IGF-1 pathway.
引用
收藏
页码：1424 / 1432
页数：9
相关论文
共 50 条
  • [21] Cynaroside extends lifespan and improves the neurondegeneration diseases via insulin/IGF-1 signaling pathway in Caenorhabditis elegans
    Xiao, Yi
    Zhang, Yan
    Li, Linlu
    Jiang, Nian
    Yu, Changyan
    Li, Sanhua
    Zhu, Xinting
    Liu, Fang
    Liu, Yun
    ARCHIVES OF GERONTOLOGY AND GERIATRICS, 2024, 122
  • [22] Caenorhabditis elegans Model to Test the Effect of Pharmacological Drugs on IGF-1/insulin Signalling Pathway
    Kumar, Jitendra
    Awasthi, Anjali
    Park, Kyung-Chae
    Singh, Vijay Kumar
    Prasad, Birendra
    JOURNAL OF DIABETES & METABOLISM, 2015, 6 (11)
  • [23] Considering Caenorhabditis elegans Aging on a Temporal and Tissue Scale: The Case of Insulin/IGF-1 Signaling
    Fabrizio, Paola
    Alcolei, Allan
    Solari, Florence
    CELLS, 2024, 13 (03)
  • [24] PM2.5 induce lifespan reduction, insulin/IGF-1 signaling pathway disruption and lipid metabolism disorder in Caenorhabditis elegans
    Zhang, Wenjing
    Li, Zinan
    Li, Guojun
    Kong, Ling
    Jing, Haiming
    Zhang, Nan
    Ning, Junyu
    Gao, Shan
    Zhang, Yong
    Wang, Xinyu
    Tao, Jing
    FRONTIERS IN PUBLIC HEALTH, 2023, 11
  • [25] Lysine-glucose Maillard reaction products promote longevity and stress tolerance in Caenorhabditis elegans via the insulin/IGF-1 signaling pathway
    Yokoyama, Issei
    Setoyama, Ou
    Urakawa, Ayumi
    Sugawara, Momo
    Jia, Yaqi
    Komiya, Yusuke
    Nagasao, Jun
    Arihara, Keizo
    JOURNAL OF FUNCTIONAL FOODS, 2021, 87
  • [26] Cytoplasmic LSM-1 protein regulates stress responses through the insulin/IGF-1 signaling pathway in Caenorhabditis elegans
    Cornes, Eric
    Porta-de-la-Riva, Montserrat
    Aristizabal-Corrales, David
    Maria Brokate-Llanos, Ana
    Javier Garcia-Rodriguez, Francisco
    Ertl, Iris
    Diaz, Monica
    Fontrodona, Laura
    Reis, Kadri
    Johnsen, Robert
    Baillie, David
    Munoz, Manuel J.
    Sarov, Mihail
    Dupuy, Denis
    Ceron, Julian
    RNA, 2015, 21 (09) : 1544 - 1553
  • [27] Ellagic Acid Increases Stress Resistance via Insulin/IGF-1 Signaling Pathway in Caenorhabditis elegans
    Bai, Shuju
    Yu, Yaoru
    An, Lu
    Wang, Wenbo
    Fu, Xueqi
    Chen, Jing
    Ma, Junfeng
    MOLECULES, 2022, 27 (19):
  • [28] Chronic Exposure to Perfluorooctane Sulfonate Reduces Lifespan of Caenorhabditis elegans Through Insulin/IGF-1 Signaling
    Tiantian Xu
    Ping Li
    Siyu Wu
    Dan Li
    Jingxuan Wu
    Kathleen M. Raley-Susman
    Defu He
    Bulletin of Environmental Contamination and Toxicology, 2016, 97 : 119 - 123
  • [29] Control of body size in C-elegans dependent on food and insulin/IGF-1 signal
    So, Shuhei
    Miyahara, Kohji
    Ohshima, Yasumi
    GENES TO CELLS, 2011, 16 (06) : 639 - 651
  • [30] Betulinic acid increases lifespan and stress resistance via insulin/IGF-1 signaling pathway in Caenorhabditis elegans
    Chen, Haiyan
    Li, Rongji
    Zhao, Feng
    Luan, Li
    Han, Tiantian
    Li, Zhong
    FRONTIERS IN NUTRITION, 2022, 9
12345