Development of plant-based mucosal vaccines against widespread infectious diseases

被引：4
作者：
Salyaev, Rurick K. [1 ]
Rigano, Maria Manuela [2 ]
Rekoslavskaya, Natalya I. [1 ]
机构：
[1] RAS, Siberian Branch, Siberian Inst Plant Physiol & Biochem, Irkutsk 664033, Russia
[2] Univ Naples Federico II, Dept Soil Plant Environm & Anim Prod Sci, I-80055 Portici, Italy
来源：
EXPERT REVIEW OF VACCINES | 2010年 / 9卷 / 08期
关键词：
hepatitis B; HIV; mucosal immunization; Nicotiana spp; tomato; transgenic plant; tuberculosis; vaccine; TOXIN-B-SUBUNIT; VIRUS-LIKE PARTICLES; ENTEROTOXIGENIC ESCHERICHIA-COLI; HEAT-LABILE ENTEROTOXIN; HIGH-LEVEL EXPRESSION; HEPATITIS-B; TUBERCULOSIS ANTIGEN; GENE-EXPRESSION; GLOBAL STRATEGY; SURFACE-ANTIGEN;
D O I：
10.1586/ERV.10.81
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Mucosal vaccination is a perspective for the control of infectious diseases, since it is capable of inducing humoral and cell-mediated responses. In addition, the delivery of vaccines to mucosal surfaces makes immunization practice safe and acceptable, and eliminates needle-associated risks. Transgenic plants can be used as bioreactors for the production of mucosally delivered protective antigens. This technology shows great promise to simplify and decrease the cost of vaccine delivery. Herein, we review the development of mucosally administered vaccines expressed in transgenic plants. In particular, we evaluate the advantages and disadvantages of using plants for the production of mucosal vaccines against widespread infectious diseases such as HIV, hepatitis B and TB.
引用
收藏
页码：937 / 946
页数：10
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