Efficient protocol for the phosphine-free Suzuki-Miyaura reaction catalyzed by palladium on carbon at room temperature

被引：81

作者：

Zhang, GL ^{[1
]}

机构：

[1] Zhejiang Univ, Coll Pharmaceut Sci, Dept Med Chem, Hangzhou 310031, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2005年 / 04期

关键词：

Suzuki-Miyaura coupling; palladium; catalysis; heterogeneous;

D O I：

10.1055/s-2004-837298

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mild and efficient protocol for the phosphine-free Suzuki-Miyaura coupling reaction of aryl bromides with arylboronic acids has been developed which utilizes the commercially available 10% Pd/C (3.5 mol% Pd) in ethanol-water (1:1) and Na2CO3 at room temperature. The reaction is convenient, environmentally benign and generates excellent yields of the coupled products (94-100%). The catalyst can be recycled using simple filtration and washing sequences without significant decrease in the yield of coupling product up to the fourth run.

引用

页码：537 / 542

页数：6

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