Evolution of microRNAs located within Hox gene clusters

被引：132

作者：

Tanzer, A

Amemiya, CT

Kim, CB

Stadler, PF

机构：

[1] Univ Leipzig, Bioinformat Grp, Dept Comp Sci, D-04103 Leipzig, Germany

[2] Univ Leipzig, Interdisciplinary Ctr Bioinformat, D-04103 Leipzig, Germany

[3] Univ Vienna, Dept Theoret Chem & Struct Biol, A-1090 Vienna, Austria

[4] Benaroya Res Inst, Virginia Mason Res Ctr, Dept Mol Genet, Seattle, WA 98101 USA

[5] Korea Res Inst Biosci & Biotechnol, Natl Genome Informat Ctr, Taejon 305333, South Korea

来源：

JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION | 2005年 / 304B卷 / 01期

关键词：

D O I：

10.1002/jez.b.21021

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

MicroRNAs (miRNAs) form an abundant class of non-coding RNA genes that have an important function in post-transcriptional gene regulation and in particular modulate the expression of developmentally important transcription factors including Hox genes. Two families of microRNAs are genomically located in intergenic regions in the Hox clusters of vertebrates. Here we describe their evolution in detail. We show that the micro RNAs closely follow the patterns of protein evolution in the Hox clusters, which is characterized by cluster duplications followed by differential gene loss. (C) 2005 Wiley-Liss, Inc.

引用

页码：75 / 85

页数：11

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