Molecular diagnostic and drug delivery agents based on aptamer-nanomaterial conjugates

被引：240

作者：

Lee, Jung Heon ^{[2
,5
]}

Yigit, Mehmet V. ^{[3
,5
]}

Mazumdar, Debapriya ^{[1
,5
]}

Lu, Yi ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ Illinois, Dept Chem, Urbana, IL 61801 USA

[2] Univ Illinois, Dept Mat Sci & Engn, Urbana, IL 61801 USA

[3] Univ Illinois, Ctr Biophys & Computat Biol, Urbana, IL 61801 USA

[4] Univ Illinois, Dept Biochem, Urbana, IL 61801 USA

[5] Univ Illinois, Beckman Inst Adv Sci & Technol, Urbana, IL 61801 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2010年 / 62卷 / 06期

基金：

美国国家科学基金会;

关键词：

DNA; Aptamer; Nanomaterials; Diagnostics; Biosensor; Drug delivery; Biomedical; Targeted therapeutics; IN-VITRO SELECTION; SINGLE-STRANDED-DNA; FREE COLORIMETRIC DETECTION; DNAZYME CATALYTIC BEACONS; WALLED CARBON NANOTUBES; LABEL-FREE; GOLD NANOPARTICLES; QUANTUM-DOT; SYSTEMATIC EVOLUTION; SURFACE IMMOBILIZATION;

D O I：

10.1016/j.addr.2010.03.003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Recent progress in an emerging area of designing aptamer and nanomaterial conjugates as molecular diagnostic and drug delivery agents in biomedical applications is summarized. Aptamers specific for a wide range of targets are first introduced and compared to antibodies. Methods of integrating these aptamers with a variety of nanomaterials, such as gold nanoparticles, quantum dots, carbon nanotubes, and superparamagnetic iron oxide nanoparticles, each with unique optical, magnetic, and electrochemical properties, are reviewed. Applications of these systems as fluorescent, colorimetric, magnetic resonance imaging, and electrochemical sensors in medical diagnostics are given, along with new applications as smart drug delivery agents. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：592 / 605

页数：14

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