Molecular diagnostic and drug delivery agents based on aptamer-nanomaterial conjugates

被引：238
作者：
Lee, Jung Heon [2 ,5 ]
Yigit, Mehmet V. [3 ,5 ]
Mazumdar, Debapriya [1 ,5 ]
Lu, Yi [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Univ Illinois, Dept Chem, Urbana, IL 61801 USA
[2] Univ Illinois, Dept Mat Sci & Engn, Urbana, IL 61801 USA
[3] Univ Illinois, Ctr Biophys & Computat Biol, Urbana, IL 61801 USA
[4] Univ Illinois, Dept Biochem, Urbana, IL 61801 USA
[5] Univ Illinois, Beckman Inst Adv Sci & Technol, Urbana, IL 61801 USA
来源：
ADVANCED DRUG DELIVERY REVIEWS | 2010年 / 62卷 / 06期
基金：
美国国家科学基金会;
关键词：
DNA; Aptamer; Nanomaterials; Diagnostics; Biosensor; Drug delivery; Biomedical; Targeted therapeutics; IN-VITRO SELECTION; SINGLE-STRANDED-DNA; FREE COLORIMETRIC DETECTION; DNAZYME CATALYTIC BEACONS; WALLED CARBON NANOTUBES; LABEL-FREE; GOLD NANOPARTICLES; QUANTUM-DOT; SYSTEMATIC EVOLUTION; SURFACE IMMOBILIZATION;
D O I：
10.1016/j.addr.2010.03.003
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Recent progress in an emerging area of designing aptamer and nanomaterial conjugates as molecular diagnostic and drug delivery agents in biomedical applications is summarized. Aptamers specific for a wide range of targets are first introduced and compared to antibodies. Methods of integrating these aptamers with a variety of nanomaterials, such as gold nanoparticles, quantum dots, carbon nanotubes, and superparamagnetic iron oxide nanoparticles, each with unique optical, magnetic, and electrochemical properties, are reviewed. Applications of these systems as fluorescent, colorimetric, magnetic resonance imaging, and electrochemical sensors in medical diagnostics are given, along with new applications as smart drug delivery agents. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码：592 / 605
页数：14
相关论文
共 182 条
  • [1] Nanotubes from carbon
    Ajayan, PM
    [J]. CHEMICAL REVIEWS, 1999, 99 (07) : 1787 - 1799
  • [2] Semiconductor clusters, nanocrystals, and quantum dots
    Alivisatos, AP
    [J]. SCIENCE, 1996, 271 (5251) : 933 - 937
  • [3] Quantum dot - Aptamer conjugates for synchronous cancer imaging, therapy, and sensing of drug delivery based on Bi-fluorescence resonance energy transfer
    Bagalkot, Vaishali
    Zhang, Liangfang
    Levy-Nissenbaum, Etgar
    Jon, Sangyong
    Kantoff, Philip W.
    Langer, Robert
    Farokhzad, Omid C.
    [J]. NANO LETTERS, 2007, 7 (10) : 3065 - 3070
  • [4] An aptamer-doxorubicin physical conjugate as a novel targeted drug-delivery platform
    Bagalkot, Vaishali
    Farokhzad, Omid C.
    Langer, Robert
    Jon, Sangyong
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (48) : 8149 - 8152
  • [5] Baker BR, 2006, J AM CHEM SOC, V128, P3138, DOI 10.1021/ja056957p
  • [6] Covalently bonded adducts of deoxyribonucleic acid (DNA) oligonucleotides with single-wall carbon nanotubes: Synthesis and hybridization
    Baker, SE
    Cai, W
    Lasseter, TL
    Weidkamp, KP
    Hamers, RJ
    [J]. NANO LETTERS, 2002, 2 (12) : 1413 - 1417
  • [7] Surface immobilization methods for aptamer diagnostic applications
    Balamurugan, Subramanian
    Obubuafo, Anne
    Soper, Steven A.
    Spivak, David A.
    [J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2008, 390 (04) : 1009 - 1021
  • [8] Surface-enhanced Raman spectroscopy of DNA
    Barhoumi, Aoune
    Zhang, Dongmao
    Tam, Felicia
    Halas, Naomi J.
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (16) : 5523 - 5529
  • [9] Systematic evolution of a DNA aptamer binding to rat brain tumor microvessels - Selective targeting of endothelial regulatory protein pigpen
    Blank, M
    Weinschenk, T
    Priemer, M
    Schluesener, H
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (19) : 16464 - 16468
  • [10] SELECTION OF SINGLE-STRANDED-DNA MOLECULES THAT BIND AND INHIBIT HUMAN THROMBIN
    BOCK, LC
    GRIFFIN, LC
    LATHAM, JA
    VERMAAS, EH
    TOOLE, JJ
    [J]. NATURE, 1992, 355 (6360) : 564 - 566
12345678910