Peptides from hydrolysate of lantern fish (Benthosema pterotum) proved neuroprotective in vitro and in vivo

被引：55

作者：

Chai, Huey-Jine ^{[1
]}

Wu, Chang-Jer ^{[2
]}

Yang, Shu-Han ^{[1
]}

Li, Tsung-Lin ^{[3
]}

Pan, Bonnie Sun ^{[2
]}

机构：

[1] Council Agr, Fisheries Res Inst, Seafood Technol Div, Keelung, Taiwan

[2] Natl Taiwan Ocean Univ, Dept Food Sci, 2 Pei Ning Rd, Keelung, Taiwan

[3] Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan

来源：

JOURNAL OF FUNCTIONAL FOODS | 2016年 / 24卷

关键词：

Benthosema pterotum; Protein hydrolysate; neuroprotective; Morris water-maze test; Brain-derived neurotrophy factor; Intracellular antioxidant; Anti-ageing; GERMINATED BROWN RICE; NEUROTROPHIC FACTOR; OXIDATIVE STRESS; CELL-DEATH; MEMORY; RAT; IMPAIRMENT; DISEASE; ACID;

D O I：

10.1016/j.jff.2016.04.009

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Benthosema pterotum is an underutilized deep-sea by-catch fish. Its protein hydrolysate (BPH) showed antioxidative activity. The BPH consisting of 13.2 mg/g of active peptides, Phe-Tyr-Tyr and Asp-Trp, significantly reduced H2O2-induced reactive oxygen species (ROS) and apoptotic cell death in human neuroblastoma SH-SY5Y cells through activation of intracellular antioxidant defence system. In Morris water-maze test, BPH was able to ameliorate memory and learning deficiency of D-galactose (D-gal)-induced neurodegenerative/ageing ICR mice. BPH-fed mice showed significantly lower levels of both D-gal-induced thiobarbituric acid reactive substances (TBARS) and endothelial nitric oxide synthase (eNOS), but higher levels of glucose-6-phosphate dehydrogenase (G6PDH) and brain-derived neurotrophy factor (BDNF) in brain of ageing mice in comparison to the control. In light of these results, BPH may be considered as a novel nutraceutical for easing the ageing and/or age-related neurodegenerative diseases. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：438 / 449

页数：12

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