Phloroglucinol derivatives guttiferone G, aristoforin, and hyperforin:: Inhibitors of human sirtuins SIRT1 and SIRT2

被引：94

作者：

Gey, Claudia

Kyrylenko, Sergiy

Hennig, Lothar

Nguyen, Lien-Hoa D.

Buettner, Anita

Pham, Hung D.

Giannis, Athanassios

机构：

[1] Univ Leipzig, Inst Organ Chem, D-04103 Leipzig, Germany

[2] Univ Kuopio, Dept Biochem, FIN-70211 Kuopio, Finland

[3] Univ Nat Sci, Dept Organ Chem, Ho Chi Minh City, Vietnam

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 27期

关键词：

enzymes; epigenetics; inhibitors; natural products;

D O I：

10.1002/anie.200605207

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Preventative medicine: The natural products guttiferone G and hyperforin (1) as well as the synthetic aristoforin (2) are inhibitors of human SIRT1 and SIRT2. Guttiferone G and 2 are less toxic but stronger inhibitors of cell proliferation than 1. These compounds may be valuable tools for epigenetics and for the elucidation of the biological role of sirtuins in processes such as cancer, ageing, neurodegenerative diseases, adipositas, and diabetes. (Chemical Equation Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

收藏

页码：5219 / 5222

页数：4

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