Lignan glycosides from the stems of Viburnum melanocarpum and their α-glucosidase inhibitory activity

被引：6

作者：

Zhao, Chunchao ^{[1
]}

Chen, Jia ^{[1
,2
]}

Shao, Jianhua ^{[2
]}

Shen, Jie ^{[1
,2
]}

Gu, Wenyan ^{[2
]}

Zhang, Xiaohui ^{[2
]}

Sha, Yusi ^{[1
]}

机构：

[1] Yangzhou Univ, Coll Biosci & Biotechnol, Yangzhou 225009, Jiangsu, Peoples R China

[2] Yangzhou Univ, Jiangsu Key Lab Crop Genet & Physiol, Coinnovat Ctr Modern Prod Technol Grain Crops, Yangzhou 225009, Jiangsu, Peoples R China

来源：

HOLZFORSCHUNG | 2020年 / 74卷 / 01期

基金：

中国国家自然科学基金;

关键词：

alpha-glucosidase inhibitory activity; Adoxaceae; lignan glycoside; Viburnum melanocarpum; CONSTITUENTS;

D O I：

10.1515/hf-2019-0159

中图分类号：

S7 [林业];

学科分类号：

0829 ; 0907 ;

摘要：

Two new lignan glycosides (1, 2) and four known lignan glycosides (3-6) have been isolated from the ethanolic extract of the stems of Viburnum melanocarpum through repeated column chromatography. Their structures including absolute configurations were confirmed by spectroscopic data [one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR), high-resolution electrospray ionization mass spectra (HRESIMS), optical rotatory dispersion (ORD) and circular dichroism (CD)] and chemical methods. Additionally, the alpha-glucosidase inhibitory activity of these compounds was tested in vitro. Compound 1 exhibited the strongest inhibitory activity against alpha-glucosidase with a half-maximal inhibitory concentration (IC50) value of 10.3 mu M.

引用

页码：88 / 93

页数：6

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