Gene Expression Studies in Mosquitoes

被引:22
作者
Chen, Xiao-Guang [1 ]
Mathur, Geetika [2 ]
James, Anthony A. [2 ,3 ]
机构
[1] So Med Univ, Sch Publ Hlth & Trop Med, Dept Parasitol, Guangzhou 510515, Guangdong, Peoples R China
[2] Univ Calif Irvine, Dept Mol Biol & Biochem, Irvine, CA 92697 USA
[3] Univ Calif Irvine, Dept Microbiol & Mol Genet, Irvine, CA 92697 USA
来源
ADVANCES IN GENETICS, VOL 64 | 2008年 / 64卷
关键词
D O I
10.1016/S0065-2660(08)00802-X
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Research on gene expression in mosquitoes is motivated by both basic and applied interests. Studies of genes involved in hematophagy, reproduction, olfaction, and immune responses reveal an exquisite confluence of biological adaptations that result in these highly-successful life forms. The requirement of female mosquitoes for a bloodmeal for propagation has been exploited by a wide diversity of viral, protozoan and metazoan pathogens as part of their life cycles. Identifying genes involved in host-seeking, blood feeding and digestion, reproduction, insecticide resistance and susceptibility/refractoriness to pathogen development is expected to provide the bases for the development of novel methods to control mosquito-borne diseases. Advances in mosquito transgenesis technologies, the availability of whole genome sequence information, mass sequencing and analyses of transcriptomes and RNAi techniques will assist development of these tools as well as deepen the understanding of the underlying genetic components for biological phenomena characteristic of these insect species. (C) 2008, Elsevier Inc.
引用
收藏
页码:19 / 50
页数:32
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