Does percutaneous coronary stent implantation increase platelet reactivity?

被引：7
作者：
Janssen, P. W. A. [1 ,2 ]
Mol, E. A. [1 ,2 ,3 ]
Geene, S. M. C. [1 ,2 ]
Barbato, E. [4 ,5 ]
ten Berg, J. M. [1 ,2 ]
机构：
[1] St Antonius Hosp, Dept Cardiol, Nieuwegein, Netherlands
[2] St Antonius Hosp, St Antonius Ctr Platelet Funct Res, Nieuwegein, Netherlands
[3] Univ Med Ctr Utrecht, Lab Expt Cardiol, Dept Cardiol, Utrecht, Netherlands
[4] Aalst OLV Hosp, Cardiovasc Res Ctr, Aalst, Belgium
[5] Univ Naples Federico II, Dept Adv Biomed Sci, Naples, Italy
来源：
BLOOD REVIEWS | 2017年 / 31卷 / 05期
关键词：
Percutaneous coronary intervention; Stenting; Platelet reactivity; Clopidogrel; ELEVATION MYOCARDIAL-INFARCTION; FUNCTION TESTS; CLOPIDOGREL; INTERVENTION; ANGIOPLASTY; ACTIVATION; THROMBOSIS; BLOOD; TRIAL; RESPONSIVENESS;
D O I：
10.1016/j.blre.2017.03.003
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
High platelet reactivity (PR) values on treatment with clopidogrel are associated with an increased rate of thrombotic events after a percutaneous coronary intervention (PCI). However, we do not know the optimal timing of the performance of the PR measurements. Platelets might be activated during a PCI, which means that the timing of PR measurements, before or after PCI, could influence the outcome. In turn, this could lead to misinterpretation of the patient's response to antiplatelet therapy and a less accurate prediction of the patient's risk of thrombotic events during follow-up. We aimed to evaluate the effect of stent implantation on PR in patients with and without acute coronary syndromes who undergo PCI to assess the optimal timing of PR measurements. A systematic literature search was performed and the results are summarized in this review. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：271 / 275
页数：5
相关论文
共 36 条
  • [1] Decreased platelet reactivity in blood anticoagulated with bivalirudin or enoxaparin compared with unfractionated heparin: Implications for coronary intervention
    Aggarwal, A
    Sobel, BE
    Schneider, DJ
    [J]. JOURNAL OF THROMBOSIS AND THROMBOLYSIS, 2002, 13 (03) : 161 - 165
  • [2] Consensus and Future Directions on the Definition of High On-Treatment Platelet Reactivity to Adenosine Diphosphate
    Bonello, Laurent
    Tantry, Udaya S.
    Marcucci, Rossella
    Blindt, Ruediger
    Angiolillo, Dominick J.
    Becker, Richard
    Bhatt, Deepak L.
    Cattaneo, Marco
    Collet, Jean Philippe
    Cuisset, Thomas
    Gachet, Christian
    Montalescot, Gilles
    Jennings, Lisa K.
    Kereiakes, Dean
    Sibbing, Dirk
    Trenk, Dietmar
    Van Werkum, Jochem W.
    Paganelli, Franck
    Price, Matthew J.
    Waksman, Ron
    Gurbel, Paul A.
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2010, 56 (12) : 919 - 933
  • [3] Comparison of Platelet Function Tests in Predicting Clinical Outcome in Patients Undergoing Coronary Stent Implantation
    Breet, Nicoline J.
    van Werkum, Jochem W.
    Bouman, Heleen J.
    Kelder, Johannes C.
    Ruven, Henk J. T.
    Bal, Egbert T.
    Deneer, Vera H.
    Harmsze, Ankie M.
    van der Heyden, Jan A. S.
    Rensing, Benno J. W. M.
    Suttorp, Maarten J.
    Hackeng, Christian M.
    ten Berg, Jurrien M.
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2010, 303 (08): : 754 - 762
  • [4] Prospective Evaluation of On-Clopidogrel Platelet Reactivity Over Time in Patients Treated With Percutaneous Coronary Intervention Relationship With Gene Polymorphisms and Clinical Outcome
    Campo, Gianluca
    Parrinello, Giovanni
    Ferraresi, Paolo
    Lunghi, Barbara
    Tebaldi, Matteo
    Miccoli, Matteo
    Marchesini, Jlenia
    Bernardi, Francesco
    Ferrari, Roberto
    Valgimigli, Marco
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2011, 57 (25) : 2474 - 2483
  • [5] Catheter thrombosis and percutaneous coronary intervention: fundamental perspectives on blood, artificial surfaces and antithrombotic drugs
    Chan, Mark Y.
    Weitz, Jeffrey I.
    Merhi, Yahye
    Harrington, Robert A.
    Becker, Richard C.
    [J]. JOURNAL OF THROMBOSIS AND THROMBOLYSIS, 2009, 28 (03) : 366 - 380
  • [6] Clopidogrel Response Up to Six Months After Acute Myocardial Infarction
    Codner, Pablo
    Vaduganathan, Muthiah
    Rechavia, Eldad
    Iakobishvili, Zaza
    Greenberg, Gabi
    Assali, Abid
    Hasdai, David
    Battler, Alexander
    Kornowski, Ran
    Lev, Eli I.
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 2012, 110 (03) : 321 - 325
  • [7] Monitoring the Efficacy of ADP Inhibitor Treatment in Patients With Acute STEMI Post-PCI by VASP-P Flow Cytometry Assay
    Fedor, Marian
    Samos, M.
    Simonova, R.
    Fedorova, J.
    Skornova, I.
    Duraj, L.
    Stasko, J.
    Kovar, F.
    Mokan, M.
    Kubisz, P.
    [J]. CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, 2015, 21 (04) : 334 - 338
  • [8] Variability of on-treatment platelet reactivity in patients on clopidogrel
    Freynhofer, Matthias K.
    Bruno, Veronika
    Brozovic, Ivan
    Jarai, Rudolf
    Vogel, Birgit
    Farhan, Serdar
    Huebl, Wolfgang
    Willheim, Martin
    Wojta, Johann
    Huber, Kurt
    [J]. PLATELETS, 2014, 25 (05) : 328 - 336
  • [9] Heparin promotes platelet responsiveness by potentiating αIIbβ3-mediated outside-in signaling
    Gao, Cunji
    Boylan, Brian
    Fang, Juan
    Wilcox, David A.
    Newman, Debra K.
    Newman, Peter J.
    [J]. BLOOD, 2011, 117 (18) : 4946 - 4952
  • [10] Low response to clopidogrel is associated with cardiovascular outcome after coronary stent implantation
    Geisler, Tobias
    Langer, Harald
    Wydymus, Magdalena
    Goehring, Katrin
    Zuern, Christine
    Bigalke, Boris
    Stellos, Konstantinos
    May, Andreas E.
    Gawaz, Meinrad
    [J]. EUROPEAN HEART JOURNAL, 2006, 27 (20) : 2420 - 2425
1234